In this study, d-penicillamine-functionalized graphene quantum dots (DPA-GQD) has been synthesized, which significantly increases the fluorescence intensity of GQD. We used this simple fluorescent probe for metal ions detection in human plasma samples. Designed DPA-GQD respond to Hg2+ , Cu2+ , Au2+ , Ag+ , Co2+ , Zn2+ , and Pb2+ with high sensitivity. The fluorescence intensity of this probe decreased significantly in the presence of metal ions such as, Hg2+ , Cu2+ , Au2+ , Ag+ , Co2+ , Zn2+ , and Pb2+ . In this work, a promising probe for ions monitoring was introduced. Moreover, DPA-GQD probe has been tested in plasma samples. The functionalized DPA-GQDs exhibits great promise as an alternative to previous fluorescent probes for bio-labeling, sensing, and other biomedical applications in aqueous solution.

中文翻译：

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基于 d-青霉胺功能化石墨烯量子点的新型光学探针：作为信号放大元件的制备和应用，以减少人体生物体液中的离子。

本研究合成了 d-青霉胺功能化石墨烯量子点 (DPA-GQD)，显着提高了 GQD 的荧光强度。我们使用这种简单的荧光探针检测人体血浆样品中的金属离子。设计的 DPA-GQD 对 Hg2+、Cu2+、Au2+、Ag+、Co2+、Zn2+ 和 Pb2+ 具有高灵敏度。在Hg2+、Cu2+、Au2+、Ag+、Co2+、Zn2+、Pb2+等金属离子存在下，该探针的荧光强度显着降低。在这项工作中，介绍了一种有前途的离子监测探针。此外，DPA-GQD 探针已在血浆样品中进行了测试。功能化的 DPA-GQD 具有巨大的潜力，可以替代以前的荧光探针，用于水溶液中的生物标记、传感和其他生物医学应用。