Organophosphorus nerve agents are highly toxic because they inhibit acetylcholinesterase activity, thereby causing a series of symptomatic poisoning. Upon entering the body, nerve agents bind active amino acid residues to form phosphonylated adducts. A potentially beneficial method for specific verification of exposure of nerve agents is based on albumin adducts, which have a half‐life of 18 days. This appears to be more effective than the fluoride reactivation method, based on acetylcholinesterase.

中文翻译：

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鉴定人血清白蛋白上的S419作为沙林和环沙林暴露的新型生物标志物

有机磷神经毒剂具有高毒性，因为它们抑制乙酰胆碱酯酶活性，从而引起一系列症状性中毒。进入人体后，神经毒剂会结合活性氨基酸残基形成膦酰化加合物。一种具体验证神经毒剂暴露的潜在有益方法是基于白蛋白加合物，其半衰期为18天。这似乎比基于乙酰胆碱酯酶的氟化物再活化方法更有效。