ABSTRACT Multimodal imaging, as an important approach to circumvent the limitations of single imaging modality, has attracted extensive attention in recent years. With the rapid development of nanotechnology and the ongoing efforts to improve their targeting capability and endow multiple imaging ability, nanoprobes are expected to play crucial roles in multimodal imaging through integrating different imaging moieties or molecules into a single nanoparticle, where silica has been used intensively as a carrier or a medium for the construction of the nanoprobes due to its preferable characteristics including good biocompatibility, long blood circulation time, and ease of modification. Based on the types of the silica used for the fabrication of nanoprobes, solid silica-based and mesoporous silica-based nanoparticles were developed for multimodal imaging. Herein, the newly developed silica-based nanoparticles as multimodal imaging agents for disease diagnosis and therapy in the last 5 years were summarized, along with their fabrication process, specific applications, and especially the role of the silica.

中文翻译：

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二氧化硅基纳米粒子在多模态生物成像中的应用

摘要 多模态成像作为规避单一成像模态局限性的重要方法，近年来受到广泛关注。随着纳米技术的快速发展和不断提高其靶向能力和赋予多重成像能力的努力，纳米探针有望通过将不同的成像部分或分子整合到单个纳米颗粒中而在多模态成像中发挥关键作用，其中二氧化硅已被广泛用作由于其具有良好的生物相容性、较长的血液循环时间和易于修饰的特性，因此是用于构建纳米探针的载体或介质。根据用于制造纳米探针的二氧化硅的类型，固体二氧化硅基和介孔二氧化硅基纳米粒子被开发用于多模态成像。在此，总结了近 5 年来新开发的二氧化硅基纳米粒子作为疾病诊断和治疗的多模态显像剂，以及它们的制备工艺、具体应用，尤其是二氧化硅的作用。