Echinococcosis is a zoonotic disease caused by cestode species of the genus Echinococcus, which demonstrates considerable medical and veterinary concerns. The development of novel drugs for echinococcosis treatment is urgently needed. In this study, we demonstrated that lonidamine (LND) and 6-aminonicotinamide (6-AN) exhibited considerable in vitro effects against both larval- and adult-stage of E. granulosussensu stricto (s. s.) and E. multilocularis. The combination of LND and 6-AN exhibited a significantly higher activity than the single drug treatment. These results highlight the therapeutic potential of LND, 6-AN and the combination of LND and 6-AN for the treatment of echinococcosis.

中文翻译：

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来那敏和6-氨基烟酰胺对细粒棘球and和多眼棘球E的体外作用。

棘球co虫病是由棘球E虫属的种皮动物引起的一种人畜共患疾病，这显示出相当大的医学和兽医问题。迫切需要开发用于治疗棘球co虫病的新药。在这项研究中，我们证明了多巴胺大肠埃希氏菌（ss）和多叶性大肠杆菌（E. granulosussensu stricto（ss））的幼虫期和成年期均具有lonidamine（LND）和6-氨基烟酰胺（6-AN）的体外效应。LND和6-AN的组合显示出比单药治疗显着更高的活性。这些结果突出了LND，6-AN以及LND和6-AN的组合在治疗棘球co病中的治疗潜力。