BACKGROUND Phase lag entropy (PLE) is a novel anesthetic depth indicator that uses four-channel electroencephalography (EEG) to measure the temporal pattern diversity in the phase relationship of frequency signals in the brain. The purpose of the study was to evaluate the anesthetic depth monitoring using PLE and to evaluate the correlation between PLE and bispectral index (BIS) values during propofol anesthesia. METHODS In thirty-five adult patients undergoing elective surgery, anesthesia was induced with propofol using target-controlled infusion (the Schneider model). We recorded the PLE value, raw EEG, BIS value, and hemodynamic data when the target effect-site concentration (Ce) of propofol reached 2, 3, 4, 5, and 6 μg/ml before intubation and 6, 5, 4, 3, 2 μg/ml after intubation and injection of muscle relaxant. We analyzed whether PLE and raw EEG data from the PLE monitor reflected the anesthetic depth as the Ce of propofol changed, and whether PLE values were comparable to BIS values. RESULTS PLE values were inversely correlated to changes in propofol Ce (propofol Ce from 0 to 6.0 μg/ml, r2 = - 0.83; propofol Ce from 6.0 to 2.0 μg/ml, r2 = - 0.46). In the spectral analysis of EEG acquired from the PLE monitor, the persistence spectrogram revealed a wide distribution of power at loss of consciousness (LOC) and recovery of consciousness (ROC), with a narrow distribution during unconsciousness. The power spectrogram showed the typical pattern seen in propofol anesthesia with slow alpha frequency band oscillation. The PLE value demonstrated a strong correlation with the BIS value during the change in propofol Ce from 0 to 6.0 μg/ml (r2 = 0.84). PLE and BIS values were similar at LOC (62.3 vs. 61.8) (P > 0.05), but PLE values were smaller than BIS values at ROC (64.4 vs 75.7) (P < 0.05). CONCLUSIONS The PLE value is a useful anesthetic depth indicator, similar to the BIS value, during propofol anesthesia. Spectral analysis of EEG acquired from the PLE monitor demonstrated the typical patterns seen in propofol anesthesia. TRIAL REGISTRATION This clinical trial was retrospectively registered at ClinicalTrials.gov at October 2017 (NCT03299621).

中文翻译：

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异丙酚麻醉期间使用相位滞后熵监测麻醉深度和脑电图带功率。

背景技术相位滞后熵（PLE​​）是一种新颖的麻醉深度指示器，其使用四通道脑电图（EEG）来测量大脑中频率信号的相位关系中的时间模式多样性。这项研究的目的是评估使用PLE麻醉深度监测并评估异丙酚麻醉期间PLE与双光谱指数（BIS）值之间的相关性。方法在35例接受择期手术的成年患者中，使用靶控输注（Schneider模型）的异丙酚诱导麻醉。当插管前异丙酚的目标作用部位浓度（Ce）达到2、3、4、5和6μg/ ml以及插管前6、5、4时，我们记录PLE值，原始EEG，BIS值和血液动力学数据。 3，插管和注射肌肉松弛剂后2μg/ ml。我们分析了当异丙酚Ce改变时，PLE监测器的PLE和原始EEG数据是否反映了麻醉深度，以及PLE值是否与BIS值相当。结果PLE值与丙泊酚Ce的变化呈反相关（丙泊酚Ce从0到6.0μg/ ml，r2 =-0.83；丙泊酚Ce从6.0到2.0μg/ ml，r2 =-0.46）。在从PLE监控器获得的脑电图的频谱分析中，持久性频谱图显示失去意识（LOC）和恢复意识（ROC）时功率分布较宽，而意识不到时分布较窄。功率谱图显示了丙泊酚麻醉中出现的典型模式，α频带振荡缓慢。PLE值在丙泊酚Ce从0改变为6.0μg/ ml（r2 = 0.84）期间证明与BIS值有很强的相关性。LOC的PLE和BIS值相似（62.3 vs. 61.8）（P> 0.05），但是PLE值小于ROC的BIS值（64.4 vs 75.7）（P <0.05）。结论PLE值是异丙酚麻醉期间与BIS值相似的有用的麻醉深度指示剂。从PLE监护仪获得的脑电图谱分析显示了异丙酚麻醉中的典型模式。试验注册该临床试验已于2017年10月在ClinicalTrials.gov上进行回顾性注册（NCT03299621）。从PLE监护仪获得的脑电图谱分析显示了异丙酚麻醉中的典型模式。试验注册该临床试验已于2017年10月在ClinicalTrials.gov上进行回顾性注册（NCT03299621）。从PLE监护仪获得的脑电图谱分析显示了异丙酚麻醉中的典型模式。试验注册该临床试验已于2017年10月在ClinicalTrials.gov上进行回顾性注册（NCT03299621）。