BACKGROUND Herpes zoster (HZ) and herpes zoster ophthalmicus (HZO) are common and debilitating diseases. There is no consensus in the literature whether HZ and HZO exhibit seasonal patterns. OBJECTIVES To determine whether HZ and HZO are seasonal. STUDY DESIGN All patients in the OptumLabs® Data Warehouse (OLDW), a longitudinal, insurance claims database with de-identified lives between January 1, 2006 and December 31, 2017 with 365 days or more of continuous enrollment were considered in the study. The database was queried for patients reporting a new ICD-9/ICD-10 code for HZ or HZO and monthly counts of each administrative code were modeled using Morelet wavelets and analyzed for annual periodicity using Fisher's g test. RESULTS There were a total of 513,911 new cases of HZ during this time period; 40,166 cases (7.8 %) were reported as HZO. Administrative coding for new cases of HZ exhibited annual periodicity (P < .001) with a peak in the summer. No periodicity was evident for HZO. CONCLUSIONS These results contribute to a growing body of evidence suggesting that HZ may be seasonal and help characterize the epidemiology of this common, painful disease.

中文翻译：

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带状疱疹和带状疱疹眼科的季节性。

背景技术带状疱疹(HZ)和眼部带状疱疹(HZO)是常见且使人衰弱的疾病。HZ 和 HZO 是否表现出季节性模式在文献中没有达成共识。目的 确定 HZ 和 HZO 是否是季节性的。研究设 查询数据库中报告 HZ 或 HZO 的新 ICD-9/ICD-10 代码的患者，并使用 Morelet 小波对每个管理代码的每月计数进行建模，并使用 Fisher 的 g 检验分析年度周期性。结果在此期间共新增HZ病例513,911例；40,166 例 (7. 8 %) 报告为 HZO。HZ 新病例的行政编码表现出年度周期性（P < .001），并在夏季达到高峰。HZO 没有明显的周期性。结论 这些结果有助于越来越多的证据表明 HZ 可能是季节性的，并有助于表征这种常见的、痛苦的疾病的流行病学。