Recent advances of nanomedicines for liver cancer therapy.,Journal of Materials Chemistry B

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Recent advances of nanomedicines for liver cancer therapy.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-05-06 , DOI: 10.1039/c9tb02871d
Xiaoqin Chi ₁ , Kun Liu ₂ , Xiangjie Luo ₂ , Zhenyu Yin ₃ , Hongyu Lin ₂ , Jinhao Gao ₂

Affiliation

Liver cancer is one of the most prevalent cancers and the third leading cause of cancer-related deaths worldwide. Liver cancer is insensitive to chemotherapeutic drugs due to its intrinsic or acquired drug resistance and the inability of delivering sufficient drugs to tumors via current chemotherapy. The emergence of nanomedicines offers a potential solution for this challenge. Nanomedicines utilize nanoscale or nanostructured materials in medicines for particular medical purposes. In this review, we illustrate the recent developments of various nanomedicines for liver cancer by presenting selected examples at different stages. Diverse nanomaterials, varied targeting moieties, and specific strategies for controlled release of nanomedicines for liver cancer therapy are summarized. Multifunctional nanomedicines for liver cancer are also discussed. This comprehensive review is aimed at providing quick access for readers to the cutting-edge nanomedicines in liver cancer therapy.

中文翻译：

用于肝癌治疗的纳米药物的最新进展。

肝癌是全球最普遍的癌症之一，也是与癌症相关的死亡的第三大主要原因。肝癌由于其固有的或获得性耐药性，并且无法通过当前的化学疗法将足够的药物传递给肿瘤，因此对化疗药物不敏感。纳米药物的出现为这一挑战提供了潜在的解决方案。纳米药物在医学中利用纳米级或纳米结构材料来实现特定的医学目的。在这篇综述中，我们通过在不同阶段展示所选的例子来说明用于肝癌的各种纳米药物的最新发展。总结了多种纳米材料，不同的靶向部分以及用于肝癌治疗的纳米药物控释的具体策略。还讨论了用于肝癌的多功能纳米药物。

更新日期：2020-02-26

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