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The case for statin use to reduce perioperative adverse cardiovascular and cerebrovascular events.
British Journal of Anaesthesia ( IF 9.1 ) Pub Date : 2020-02-25 , DOI: 10.1016/j.bja.2020.01.010
Fiona Ratcliffe 1 , Peter M Rothwell 2
Affiliation  

Ischaemic heart disease and stroke are the leading causes of death worldwide at 119 per 100,000 and 85 per 100,000 population. For the USA, heart disease is leading cause of death at 165 per 100,000 population. In developed countries, strokes and acute myocardial infarction in the general population have fallen from smoking reduction, lifestyle modifications and therapeutic interventions including statins. In a population-based stroke study in the UK involving primary care practices, of in-hospital strokes 90% were ischaemic, and 37% occurred within 1 week of an operation. Approximately 50% of the patients were not on a statin. In the UK, there is a national screening initiative for the prevention of atherosclerotic cardiovascular disease (ASCVD) offered to people aged 40-74 yr old. The QRISK3 tool calculates the risk of developing heart disease or stroke over 10 yr, from which recommendations are made on interventions for the prevention of ASCVD up to age 84 yr, with similar screening and assessment tools in Europe and the US. If the QRISK3 score tool for calculating cardiovascular risk is considered sufficiently robust for population screening in primary care, should anaesthetists not use the same screening for secondary care? We present a case for statin use over the perioperative period, to reduce early vascular adverse events based on statins' early pleiotropic actions, using the primary care QRISK tool for screening of ASCVD risk.

中文翻译:

他汀类药物用于减少围手术期不良心血管和脑血管事件的情况。

缺血性心脏病和中风是全球主要的死亡原因,分别为119 / 100,000和85 / 100,000。在美国,心脏病是导致死亡的主要原因,每10万人中有165人死亡。在发达国家,减少吸烟,改变生活方式和包括他汀类药物在内的治疗性干预措施已使普通人群的中风和急性心肌梗塞有所减少。在英国一项涉及初级保健实践的基于人群的中风研究中,院内中风中有90%是缺血性的,而37%在手术后1周内发生。大约50%的患者未使用他汀类药物。在英国,有一项针对40-74岁年龄段人群的预防动脉粥样硬化性心血管疾病(ASCVD)的国家筛查计划。QRISK3工具可计算10年以上患心脏病或中风的风险,并据此建议在欧洲和美国使用类似的筛查和评估工具,以预防84岁以下的ASCVD的干预措施。如果在初级保健中筛查心血管疾病风险的QRISK3评分工具被认为足以进行人群筛查,那么麻醉师是否应在二级保健中不使用相同的筛查方法?我们提供了一个围手术期使用他汀类药物的案例,以使用他汀类药物的早期多效性作用减少早期血管不良事件,使用初级护理QRISK工具筛查ASCVD风险。如果在初级保健中筛查心血管疾病风险的QRISK3评分工具被认为足以进行人群筛查,那么麻醉师是否应该在二级保健中不使用相同的筛查?我们提供了一个围手术期使用他汀类药物的案例,以使用他汀类药物的早期多效性行动来减少早期血管不良事件,使用初级护理QRISK工具筛查ASCVD风险。如果在初级保健中筛查心血管疾病风险的QRISK3评分工具被认为足以进行人群筛查,那么麻醉师是否应在二级保健中不使用相同的筛查方法?我们提供了一个围手术期使用他汀类药物的案例,以使用他汀类药物的早期多效性行动来减少早期血管不良事件,使用初级护理QRISK工具筛查ASCVD风险。
更新日期:2020-02-25
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