Perivascular adipose tissue (PVAT), a crucial regulator of vascular homeostasis, is actively involved in vascular dysfunction during aging. PVAT releases various adipocytokines, chemokines and growth factors. In an endocrine and paracrine manner PVAT-derived factors regulate vascular signalling and inflammation modulating functions of adjacent layers of the vasculature. Pathophysiological conditions such as obesity, type 2 diabetes, vascular injury and aging can cause PVAT dysfunction, leading to vascular endothelial and smooth muscle cell dysfunctions. We and others have suggested that PVAT is involved in the inflammatory response of the vascular wall in diet induced obesity animal models leading to vascular dysfunction due to disappearance of the physiological anticontractile effect. Previous studies confirm a crucial role for pinpointed PVAT inflammation in promoting vascular oxidative stress and inflammation in aging, enhancing the risk for development of cardiovascular disease.

In this review, we discuss several studies and mechanisms linking PVAT to age-related vascular diseases. An overview of the suggested roles played by PVAT in different disorders associated with the vasculature such as endothelial dysfunction, neointimal formation, aneurysm, vascular contractility and stiffness will be performed. PVAT may be considered a potential target for therapeutic intervention in age-related vascular disease.

血管脂肪组织（PVAT）是血管动态平衡的重要调节器，在衰老过程中积极参与血管功能障碍。PVAT释放各种脂肪细胞因子，趋化因子和生长因子。以内分泌和旁分泌方式，PVAT衍生的因子调节血管信号传导和邻近脉管系统各层的炎症调节功能。肥胖，2型糖尿病，血管损伤和衰老等病理生理状况可能导致PVAT功能障碍，从而导致血管内皮和平滑肌细胞功能障碍。我们和其他人提出，在饮食诱导的肥胖动物模型中，PVAT参与了血管壁的炎症反应，由于生理抗收缩作用的消失而导致了血管功能障碍。

在这篇综述中，我们讨论了一些将PVAT与年龄相关的血管疾病联系起来的研究和机制。将对PVAT在与脉管系统相关的不同疾病（例如内皮功能障碍，新内膜形成，动脉瘤，血管收缩性和僵硬性）中发挥的建议作用进行概述。PVAT被认为是与年龄有关的血管疾病的治疗干预措施的潜在目标。