OBJECTIVE To evaluate whether treated hypotension in the first 24 postnatal hours is associated with hearing loss in extremely low birth weight (ELBW) infants. STUDY DESIGN In a cohort of 735 ELBW infants, we identified 25 with sensorineural hearing loss (SNHL) at 12-24 months adjusted age. For each case, we selected three controls with normal hearing. Logistic regression models were used to adjust for confounding variables. RESULTS Sixty percent of cases and 25% of controls were treated for hypotension. After adjusting for confounding variables (gestational age, antenatal glucocorticoids, 5 min Apgar < 6, insertion of an umbilical catheter, treatment with high frequency ventilation, and major cranial ultrasound abnormality), treated hypotension was associated with an increased risk of SNHL (adjusted odds ratio: 3.6; 95% confidence interval: 1.3-9.7). CONCLUSIONS Treated hypotension in ELBW infants in the first 24 h of life is associated with an increased risk of SNHL.

中文翻译：

---

出生后最初 24 小时内的低血压治疗和极低出生体重婴儿听力损失的风险。

目的 评估出生后最初 24 小时内治疗的低血压是否与极低出生体重 (ELBW) 婴儿的听力损失有关。研究设计 在 735 名 ELBW 婴儿的队列中，我们确定了 25 名在 12-24 个月调整年龄时患有感音神经性听力损失 (SNHL)。对于每个案例，我们选择了三个听力正常的对照。Logistic 回归模型用于调整混杂变量。结果 60% 的病例和 25% 的对照组接受了低血压治疗。在调整混杂变量（胎龄、产前糖皮质激素、5 分钟 Apgar < 6、插入脐带导管、高频通气治疗和主要颅超声异常）后，经治疗的低血压与 SNHL 风险增加有关（调整后的几率比率：3.6；95% 置信区间：1.3-9.7）。结论 ELBW 婴儿在出生后 24 小时内接受治疗的低血压与 SNHL 风险增加相关。