Oral dextrose reduced procedural pain without altering cellular ATP metabolism in preterm neonates: a prospective randomized trial.,Journal of Perinatology

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Oral dextrose reduced procedural pain without altering cellular ATP metabolism in preterm neonates: a prospective randomized trial.
Journal of Perinatology ( IF 2.4 ) Pub Date : 2020-02-26 , DOI: 10.1038/s41372-020-0634-0
Danilyn M Angeles _{1,

2} , Danilo S Boskovic ₁ , John C Tan ₁ , Wendy Shih ₃ , Erin Hoch ₄ , Dorothy Forde ₅ , Raylene M Phillips _{2,

4} , Andrew Hopper _{2,

4} , Douglas D Deming _{2,

4} , Mitchell Goldstein _{2,

4} , Giang Truong _{2,

4} , Aprille Febre _{2,

4} , Priscilla Pegis ₄ , Adrian Lavery _{2,

4} , Munaf Kadri _{2,

4} , Anamika Banerji _{2,

4} , Iman Mousselli ₁ , Vora Farha _{2,

4} , Elba Fayard _{2,

4}

Affiliation

OBJECTIVE To examine the effects of 30% oral dextrose on biochemical markers of pain, adenosine triphosphate (ATP) degradation, and oxidative stress in preterm neonates experiencing a clinically required heel lance. STUDY DESIGN Utilizing a prospective study design, preterm neonates that met study criteria (n = 169) were randomized to receive either (1) 30% oral dextrose, (2) facilitated tucking, or (3) 30% oral dextrose and facilitated tucking 2 min before heel lance. Plasma markers of ATP degradation (hypoxanthine, uric acid) and oxidative stress (allantoin) were measured before and after the heel lance. Pain was measured using the premature infant pain profile-revised (PIPP-R). RESULTS Oral dextrose, administered alone or with facilitated tucking, did not alter plasma markers of ATP utilization and oxidative stress. CONCLUSION A single dose of 30% oral dextrose, given before a clinically required heel lance, decreased signs of pain without increasing ATP utilization and oxidative stress in premature neonates.

中文翻译：

口服葡萄糖在不改变早产新生儿细胞 ATP 代谢的情况下减轻了手术疼痛：一项前瞻性随机试验。

目的研究 30% 口服葡萄糖对经历临床要求的足跟喷枪的早产新生儿疼痛、三磷酸腺苷 (ATP) 降解和氧化应激的生化标志物的影响。研究设计利用前瞻性研究设计，符合研究标准的早产新生儿 (n = 169) 被随机分配接受 (1) 30% 口服葡萄糖，(2) 促进吞食，或 (3) 30% 口服葡萄糖和促进吞食 2脚跟枪之前的分钟。ATP 降解（次黄嘌呤、尿酸）和氧化应激（尿囊素）的血浆标志物在足跟刺针前后进行了测量。使用修订的早产儿疼痛曲线 (PIPP-R) 测量疼痛。结果口服葡萄糖，单独给药或与促进折叠一起给药，不会改变 ATP 利用率和氧化应激的血浆标志物。

更新日期：2020-02-26

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