PURPOSE Nephrogenic system fibrosis (NSF) is a rare complication detected in patients with renal insufficiency exposed to gadolinium-based contrast agents (GBCAs). The aim of our study is to evaluate the prevalence of NSF in a cohort of patients on renal replacement treatment who underwent GBCA-enhanced magnetic resonance imaging (MRI). METHOD We retrospectively reviewed all the charts of kidney transplant (KT) recipients, patients on hemodialysis (HD) and peritoneal dialysis (PD) who received a uniform protocol for contrast material enhanced-MRI with gadoteric acid at our center from January 2004 to December 2017. RESULTS Three-hundred forty-four patients (44.1% on HD, 11.3% on PD and 44.4% KT recipients) underwent 551 gadoteric acid-enhanced MRI. The median age of the patients was 58 years (IQR, 45-70 years) and 65.1% were men. Sixty-three patients (18.3%) had skin punch biopsy after integumentary assessment performed by a dermatologist. No cases of NSF were detected after a median follow-up of 4.5 years (IQR, 1.9-8.2 years). During this period of observation, 116 (33.7%) patients died and 11 (3.1%) were lost at follow-up. CONCLUSIONS None of the patients exposed to gadoteric acid developed NSF. Our results, in line with more recent studies, suggest that the use of gadoteric acid, a macrocyclic GBCA, appears safe even in chronic kidney disease (CKD) patients receiving dialysis.

中文翻译：

---

接受肾脏替代治疗的患者服用ado酸后肾病性全身纤维化的发生率。

目的肾源性系统纤维化（NSF）是暴露于以g为基础的造影剂（GBCAs）暴露的肾功能不全患者中罕见的并发症。我们研究的目的是评估在接受GBCA增强磁共振成像（MRI）的肾脏替代治疗患者中NSF的患病率。方法我们回顾性回顾了2004年1月至2017年12月在我们中心接受了统一的造影剂造影剂联合ado多酸治疗的所有肾移植（KT）受者，接受血液透析（HD）和腹膜透析（PD）的患者的图表结果344例患者接受了551例g石酸增强MRI检查（HD患者为44.1％，PD患者为11.3％，KT患者为44.4％）。患者的中位年龄为58岁（IQR，45-70岁），男性为65.1％。经过皮肤科医生的皮肤病学评估后，有63例患者（18.3％）进行了皮肤打孔活检。在中位随访4。5年（IQR，1。9-8。2年）后，未发现NSF病例。在此观察期间，随访期间有116例患者（33.7％）死亡，11例患者（3.1％）丢失。结论暴露于g酸的患者均未出现NSF。我们的结果与最近的研究一致，表明即使在接受透析的慢性肾脏病（CKD）患者中，大环GBCA ado酸也似乎是安全的。结论暴露于g酸的患者均未出现NSF。我们的结果与最近的研究一致，表明即使在接受透析的慢性肾脏病（CKD）患者中，大环GBCA ado酸也似乎是安全的。结论暴露于g酸的患者均未出现NSF。我们的结果与最近的研究一致，表明即使在接受透析的慢性肾脏病（CKD）患者中，大环GBCA ado酸也似乎是安全的。