Ochuscins A‒G (1–7), seven highly oxygenated usnic acid derivatives were isolated from the deep-sea-derived fungus Ochroconis sp. FS449. Their structures were elucidated based on the 1D, 2D NMR, HRESIMS and single crystal X-ray diffraction, while the absolute configurations were established by the quantum chemical calculations of ¹³C NMR chemical shifts as well as ECD plots. The biosynthesis pathway of 1‒7 was proposed to generate via a dimerization of phloroglucinol derivatives. In the bioassay, compounds 2, 3, 4 and 7 exhibited moderate inhibitory activities against acetylcholinesterase with the IC₅₀ values in the range from 49 to 80 μM. A preliminary structure-activity relationship was discussed.

从深海来源的真菌Ochroconis sp。中分离出了Ochuscins A‒G（1 – 7），七个高度氧化的松萝酸衍生物。FS449。通过1D，2D NMR，HRESIMS和单晶X射线衍射阐明了它们的结构，同时通过¹³ C NMR化学位移的量子化学计算以及ECD图建立了绝对构型。的生物合成途径1 - 7提出了通过间苯三酚衍生物的二聚化以产生。在生物测定中，化合物2，3，4和7具有对乙酰胆碱酯酶的中等抑制活性，IC ₅₀值为49至80μM。初步的构效关系进行了讨论。