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Exosomal Nrf2: from anti-oxidant and anti-inflammation response to wound healing and tissue regeneration in aged-related diseases.
Biochimie ( IF 3.3 ) Pub Date : 2020-02-25 , DOI: 10.1016/j.biochi.2020.02.011
Houman Kahroba 1 , Yasamin Davatgaran-Taghipour 2
Affiliation  

Accumulation of oxidative stress in cells is an essential feature of cellular senescence and aging. This phenomenon is involved in different age-related diseases through dysregulation of homeostasis and impairing repair and regeneration (wound healing) capacity, which can suppress antioxidant responses such as the activity of antioxidant enzymes and damaged protein clearance system. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor which regulates basal and inducible expression pattern of specific genes (antioxidants and detoxifications) through antioxidant element response (ARE) sites in the stress condition, specifically in chronic and age-related stresses. Nrf2 maintains cellular redox hemostasis and promotes rejuvenation. Exosomes are nanoscale vesicles that are released by various cells to actively regulate the complex cellular signaling networks. Exosomal-Nrf2 and exosomal-Nrf2-mediated products can modulate oxidative hemostasis in target cells to induce tissue repairing with therapeutic proposes, and regeneration capability. In this study, we summarized the role of exosomal-Nrf2 in different age-related diseases, including diabetic foot ulcers, atherosclerosis, chronic heart failure, reproductive cell failures, and neurodegenerative diseases. In addition, we briefly explained the crosstalk between plant exosomes and mammalian cell metabolism in the benefit of cellular stress suppression.

中文翻译:

外泌体Nrf2:从抗氧化剂和抗炎症反应到老年相关疾病的伤口愈合和组织再生。

细胞中氧化应激的积累是细胞衰老和衰老的重要特征。这种现象通过体内稳态的失调和损害修复和再生(伤口愈合)能力而涉及到各种与年龄有关的疾病,这可以抑制抗氧化反应,例如抗氧化酶的活性和受损的蛋白质清除系统。核因子红系2相关因子2(Nrf2)是一种转录因子,可通过应激条件下的抗氧化元素响应(ARE)位点调节特定基因(抗氧化剂和排毒)的基础和诱导型表达模式,特别是在慢性和与年龄相关的情况下压力。Nrf2维持细胞氧化还原止血并促进年轻化。外泌体是由各种细胞释放以主动调节复杂细胞信号网络的纳米级囊泡。外泌体Nrf2和外泌体Nrf2介导的产物可以调节靶细胞的氧化止血,从而诱导具有治疗方案和再生能力的组织修复。在这项研究中,我们总结了exosomal-Nrf2在不同的与年龄有关的疾病中的作用,包括糖尿病足溃疡,动脉粥样硬化,慢性心力衰竭,生殖细胞衰竭和神经退行性疾病。此外,我们简要解释了植物外泌体与哺乳动物细胞代谢之间的串扰,有利于抑制细胞应激。外泌体Nrf2和外泌体Nrf2介导的产物可以调节靶细胞的氧化止血,从而诱导具有治疗方案和再生能力的组织修复。在这项研究中,我们总结了exosomal-Nrf2在不同的与年龄有关的疾病中的作用,包括糖尿病足溃疡,动脉粥样硬化,慢性心力衰竭,生殖细胞衰竭和神经退行性疾病。此外,我们简要解释了植物外泌体与哺乳动物细胞代谢之间的串扰,有利于抑制细胞应激。外泌体Nrf2和外泌体Nrf2介导的产物可以调节靶细胞的氧化止血,从而诱导具有治疗方案和再生能力的组织修复。在这项研究中,我们总结了exosomal-Nrf2在不同的与年龄有关的疾病中的作用,包括糖尿病足溃疡,动脉粥样硬化,慢性心力衰竭,生殖细胞衰竭和神经退行性疾病。此外,我们简要解释了植物外泌体与哺乳动物细胞代谢之间的串扰,有利于细胞应激的抑制。
更新日期:2020-02-26
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