Organochlorine pesticides (OCPs) are persistent environmental contaminants that act as endocrine disruptors and system toxicants. These pesticides (e.g. dichlorodiphenyltrichloroethane (DDT), dieldrin, toxaphene, among others) are ranked as some of the most concerning chemicals for human health. These pesticides (1) act as teratogens, (2) are neuroendocrine disruptors, (3) suppress the immune and reproductive systems, and (4) dysregulate lipids and metabolism. Using a computational approach, we revealed enriched endocrine-related pathways in the Comparative Toxicogenomics Database sensitive to this chemical class, and these included reproduction (gonadotropins, estradiol, androgen, steroid biosynthesis, oxytocin), thyroid hormone, and insulin. Insight from the Tox21 and ToxCast programs confirm that these agrochemicals activate estrogen receptors, androgen receptors, and retinoic acid receptors with relatively high affinity, although differences exist in their potency. We propose an adverse outcome pathway for OCPs toxicity in the fish testis as a novel contribution to further understanding of OCP-induced toxicity. Organochlorine pesticides, due to their persistence and high toxicity to aquatic and terrestrial wildlife as well as humans, remain significant agrochemicals of concern.

中文翻译：

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有机氯农药：对鱼类具有强效内分泌干扰特性的农用化学品。

有机氯农药 (OCP) 是持久性环境污染物，可作为内分泌干扰物和系统毒物。这些农药（例如二氯二苯基三氯乙烷（DDT）、狄氏剂、毒杀芬等）被列为对人类健康最重要的化学物质。这些农药 (1) 具有致畸作用，(2) 是神经内分泌干扰物，(3) 抑制免疫和生殖系统，(4) 调节脂质和新陈代谢。使用计算方法，我们在比较毒物基因组学数据库中揭示了对该化学类别敏感的丰富的内分泌相关途径，其中包括生殖（促性腺激素、雌二醇、雄激素、类固醇生物合成、催产素）、甲状腺激素和胰岛素。Tox21 和 ToxCast 计划的见解证实，这些农用化学品以相对较高的亲和力激活雌激素受体、雄激素受体和视黄酸受体，尽管它们的效力存在差异。我们提出了鱼睾丸中 OCP 毒性的不良后果途径，作为进一步了解 OCP 诱导毒性的新贡献。有机氯农药由于其持久性和对水生和陆生野生动物以及人类的高毒性，仍然是令人关注的重要农用化学品。