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Acetylresveratrol as a Potential Substitute for Resveratrol Dragged the Toxic Aldehyde to Inhibit the Mutation of Mitochondrial DNA.
Applied Biochemistry and Biotechnology ( IF 3.1 ) Pub Date : 2020-02-26 , DOI: 10.1007/s12010-020-03279-w
Yanbin Su 1 , Chengyu Sun 2 , Xuwei Sun 1 , Ruixue Wu 1 , Xing Zhang 1 , Yunzhou Tu 1
Affiliation  

The aim of this study was to explore whether or not acetylresveratrol as a potential substitute for resveratrol dragged the toxic aldehyde to inhibit the mutation of mitochondrial DNA. The results revealed that the acetylresveratrol shifted ultraviolet peak of trans-crotonaldehyde from 316 to 311 nm. In mitochondria, the acetylresveratrol split the ultraviolet peak at 311 nm of trans-crotonaldehyde into 311 nm and 309 nm; the aldehyde Raman band of trans-crotonaldehyde was red shifted by the acetylresveratrol from 1689 to 1686 cm-1 with obvious band decline; Raman bands at 1149 cm-1, 1168 cm-1, and 1325 cm-1 of acetylresveratrol disappeared. In aldehyde dehydrogenase, the aldehyde Raman band of trans-crotonaldehyde was red shifted by the acetylresveratrol from 1689 to 1684 cm-1 with band decline; Raman bands at 1150 cm-1, 1168 cm-1, and 1324 cm-1 of acetylresveratrol declined. The weak acidic microenvironment was the best, for the acetylresveratrol dragged the toxic aldehyde of trans-crotonaldehyde. Compared with the resveratrol, the effect of the acetylresveratrol on the toxic aldehyde of trans-crotonaldehyde was very similar to that of the resveratrol. The acetylresveratrol is very suitable as a potential substitute for resveratrol dragged the toxic aldehyde to inhibit the mutation of mitochondrial DNA. Graphical Abstract In mitochondria, the Raman band of the toxic -CH=O of trans-crotonaldehyde (TCA) dragged by the Acetyl-Res from 1689 to 1686 cm-1 with obvious band decline, while the Raman bands at 1149 cm-1, 1168 cm-1, and 1325 cm-1 of the Acetyl-Res disappeared, respectively. The Acetyl-Res is very suitable as a potential substitute, for the Res dragged the toxic -CH=O of TCA to inhibit the mutation of mitochondrial DNA for anticancer.

中文翻译:

乙酰白藜芦醇作为白藜芦醇的潜在替代品拖延了有毒的醛抑制线粒体DNA的突变。

这项研究的目的是探讨乙酰白藜芦醇作为白藜芦醇的潜在替代品是否会拖拽有毒的醛抑制线粒体DNA的突变。结果表明,乙酰基白藜芦醇将反式巴豆醛的紫外峰从316 nm移至311 nm。在线粒体中,乙酰基白藜芦醇将反式巴豆醛在311 nm处的紫外峰分为311 nm和309 nm。乙酰白藜芦醇使反式巴豆醛的拉曼光谱带从1689年红移至1686 cm-1,谱带下降明显。乙酰白藜芦醇在1149 cm-1、1168 cm-1和1325 cm-1处的拉曼带消失了。在醛脱氢酶中,反式巴豆醛的醛拉曼光谱带被乙酰白藜芦醇从1689转移到1684 cm-1并随着谱带下降而红移。1150 cm-1、1168 cm-1,和1324 cm-1的乙酰白藜芦醇下降。弱酸性微环境是最好的,因为乙酰白藜芦醇拖累了反式巴豆醛的有毒醛。与白藜芦醇相比,乙酰基白藜芦醇对反式巴豆醛有毒醛的作用与白藜芦醇非常相似。乙酰基白藜芦醇非常适合作为白藜芦醇的潜在替代品,后者拖动有毒的醛抑制线粒体DNA的突变。图形摘要在线粒体中,有毒的-CH = O的反式巴豆醛(TCA)的拉曼谱带在1689年至1686 cm-1处被乙酰-Res拖曳,谱带明显下降,而拉曼谱带在1149 cm-1处,分别消失了1168 cm-1和1325 cm-1的乙酰基。乙酰-Res非常适合作为潜在的替代品,
更新日期:2020-02-26
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