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Consolidation of Clinical Microbiology Laboratories and Introduction of Transformative Technologies.
Clinical Microbiology Reviews ( IF 19.0 ) Pub Date : 2020-02-26 , DOI: 10.1128/cmr.00057-19
Olivier Vandenberg 1, 2 , Géraldine Durand 3 , Marie Hallin 4 , Andreas Diefenbach 5, 6 , Vanya Gant 7 , Patrick Murray 8 , Zisis Kozlakidis 9 , Alex van Belkum 10
Affiliation  

SUMMARYClinical microbiology is experiencing revolutionary advances in the deployment of molecular, genome sequencing-based, and mass spectrometry-driven detection, identification, and characterization assays. Laboratory automation and the linkage of information systems for big(ger) data management, including artificial intelligence (AI) approaches, also are being introduced. The initial optimism associated with these developments has now entered a more reality-driven phase of reflection on the significant challenges, complexities, and health care benefits posed by these innovations. With this in mind, the ongoing process of clinical laboratory consolidation, covering large geographical regions, represents an opportunity for the efficient and cost-effective introduction of new laboratory technologies and improvements in translational research and development. This will further define and generate the mandatory infrastructure used in validation and implementation of newer high-throughput diagnostic approaches. Effective, structured access to large numbers of well-documented biobanked biological materials from networked laboratories will release countless opportunities for clinical and scientific infectious disease research and will generate positive health care impacts. We describe why consolidation of clinical microbiology laboratories will generate quality benefits for many, if not most, aspects of the services separate institutions already provided individually. We also define the important role of innovative and large-scale diagnostic platforms. Such platforms lend themselves particularly well to computational (AI)-driven genomics and bioinformatics applications. These and other diagnostic innovations will allow for better infectious disease detection, surveillance, and prevention with novel translational research and optimized (diagnostic) product and service development opportunities as key results.

中文翻译:


临床微生物学实验室的整合和变革性技术的引进。



摘要临床微生物学在分子、基因组测序和质谱驱动的检测、鉴定和表征分析的部署方面正在经历革命性的进步。实验室自动化和大数据管理信息系统的链接,包括人工智能(AI)方法,也正在引入。与这些发展相关的最初乐观情绪现在已经进入一个更加现实驱动的阶段,反思这些创新带来的重大挑战、复杂性和医疗保健效益。考虑到这一点,覆盖广大地理区域的持续临床实验室整合过程为高效且经济高效地引入新实验室技术以及改进转化研究和开发提供了机会。这将进一步定义和生成用于验证和实施更新的高通量诊断方​​法的强制性基础设施。从网络实验室有效、结构化地获取大量有据可查的生物库生物材料将为临床和科学传染病研究释放无数机会,并将产生积极的医疗保健影响。我们描述了为什么临床微生物学实验室的整合将为各个机构已经单独提供的服务的许多(如果不是大多数)方面带来质量效益。我们还定义了创新和大规模诊断平台的重要作用。此类平台特别适合计算(AI)驱动的基因组学和生物信息学应用。 这些和其他诊断创新将通过新颖的转化研究和优化(诊断)产品和服务开发机会作为关键成果,实现更好的传染病检测、监测和预防。
更新日期:2020-02-26
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