The impact on survival of steroids and TNFα blockade to treat immune-related toxicity from checkpoint blockade with ipilimumab, nivolumab/pembrolizumab, or combined ipilimumab and nivolumab was assessed using data from a large national database. Using steroids was associated with better survival than the use of TNFα-blocking antibodies such as infliximab.See related article by Verheijden et al., p. 2268.

中文翻译：

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TNFα在检查点抑制中的阻滞：是好是坏，还是丑陋？

使用大型国家数据库中的数据评估了使用ipilimumab，nivolumab / pembrolizumab或ipilimumab和nivolumab合并检查点对类固醇和TNFα阻滞剂治疗免疫相关毒性对类固醇和生存的影响，该数据来自一个大型的国家数据库。与使用TNFα阻断抗体（如英夫利昔单抗）相比，使用类固醇具有更好的生存期（参见Verheijden等人，p。2268。