Influence of liquid coverage on the anticancer effects of a helium plasma jet on 3D tumor spheroids,Plasma Processes and Polymers

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Influence of liquid coverage on the anticancer effects of a helium plasma jet on 3D tumor spheroids
Plasma Processes and Polymers ( IF 2.9 ) Pub Date : 2020-02-26 , DOI: 10.1002/ppap.201900213
Jishen Zhang ₁ , Dingxin Liu ₁ , Hao Zhang ₁ , Wenjie Xia ₁ , Yifan Liu ₁ , Bowen Sun ₁ , Dehui Xu ₁ , Li Guo ₁ , Michael G. Kong _{1,

2,

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Affiliation

In clinical treatment, the presence or absence of transudate coverage of exposed tumor tissue may have a significant impact on the therapeutic effect of cold atmospheric plasma. Here, the anticancer effects of a plasma jet on three‐dimensional multicellular tumor spheroids with or without liquid coverage were examined. It was found that cell viability decreased more rapidly without liquid coverage than with liquid coverage. Apoptotic cells and reactive oxygen species (ROS) were mainly distributed in the areas of the spheroids directly irradiated by the plasma jet without liquid coverage. However, with liquid coverage, they were distributed throughout the outermost layers of the whole spheroids. Importantly, liquid can help ROS penetrate into spheroids and prolong the anticancer effects of plasma.

中文翻译：

液体覆盖范围对氦等离子体射流对3D肿瘤球体的抗癌作用的影响

在临床治疗中，裸露的肿瘤组织是否存在渗出液可能会对冷血浆的治疗效果产生重大影响。在这里，检查了血浆喷射流对有或没有液体覆盖的三维多细胞肿瘤球体的抗癌作用。发现在没有液体覆盖的情况下，细胞存活率比在液体覆盖的情况下下降得更快。凋亡细胞和活性氧（ROS）主要分布在等离子流直接照射的球体区域，没有液体覆盖。但是，在液体覆盖下，它们分布在整个球体的最外层。重要的是，液体可以帮助ROS渗透到球体中，并延长血浆的抗癌作用。

更新日期：2020-02-26

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