Modular and Customized Fabrication of 3D Functional Microgels for Bottom‐Up Tissue Engineering and Drug Screening,Advanced Materials Technologies

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Modular and Customized Fabrication of 3D Functional Microgels for Bottom‐Up Tissue Engineering and Drug Screening
Advanced Materials Technologies ( IF 6.4 ) Pub Date : 2020-02-25 , DOI: 10.1002/admt.201900847
Wenguang Yang ₁ , Shuxiang Cai ₁ , Yibao Chen ₁ , Wenfeng Liang ₂ , Youbin Lai ₃ , Haibo Yu ₄ , Yuechao Wang ₄ , Lianqing Liu ₄

Affiliation

Customized generation of 3D functional building blocks is crucial for bottom‐up tissue engineering. Currently, high throughput production, high survival rates, and well‐controlled shapes are considered as three major challenges in fabricating microgels. Here, an optofluidic maskless lithography system that combines digital micromirror device based 3D printing and microfluidic technologies for fabricating 3D functional microgels, is presented. With this system, 3D microgels can be custom designed online and manufactured modularly in a microfluidic device. The fabrication process is based on shadowed light, highly flexible, and requires no physical masks. Furthermore, cells in microgels exhibit features that are more similar to the complex in vivo conditions, including morphology, proliferation, and drug resistance.

中文翻译：

用于自下而上的组织工程和药物筛选的3D功能微凝胶的模块化和定制制造

定制生成3D功能构建块对于自下而上的组织工程至关重要。当前，高通量生产，高成活率和良好控制的形状被认为是制备微凝胶的三个主要挑战。在这里，提出了一种光流体无掩模光刻系统，该系统结合了基于数字微镜设备的3D打印和微流体技术来制造3D功能微凝胶。使用该系统，可以在线定制设计3D微凝胶，并在微流体设备中模块化制造。制造过程基于阴影光，高度灵活且不需要物理掩模。此外，微凝胶中的细胞表现出与复杂的体内条件更相似的特征，包括形态，增殖和耐药性。

更新日期：2020-02-25

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