Two ibuprofen suspension formulations were investigated for their dissolution in various bicarbonate, phosphate and acetate buffers. Phosphate and acetate gave faster release than bicarbonate at comparable molarities. Nevertheless, mass transport modelling using the reversible non-equilibrium (RNE) approach enabled the calculation of phosphate molarities that gave good matches to physiological bicarbonate in terms of ibuprofen dissolution. This shows that developing surrogate buffers for bicarbonate that are devoid of the technical difficulties associated with the bicarbonate-CO2 systems is possible. In addition, the intestinal dissolution kinetics of the tested suspensions were determined by applying compartmental pharmacokinetic modelling to plasma profiles that were previously obtained for these suspensions in an in vivo study performed on healthy human volunteers. The in vitro dissolution profiles in bicarbonate compared reasonably well with the profiles representing the in vivo intestinal dissolution kinetics of the tested suspensions when applied to healthy human volunteers in a pharmacokinetic study. This shows the possible potential toward extending biowaivers so that they include BCS class IIa compounds.

中文翻译：

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通过合理选择溶解条件，体外从悬浮液中吸收布洛芬的体外预测。

研究了两种布洛芬悬浮液制剂在各种碳酸氢盐，磷酸盐和乙酸盐缓冲液中的溶解度。在相当的摩尔浓度下，磷酸盐和乙酸盐的释放速度比碳酸氢盐释放速度快。然而，使用可逆非平衡（RNE）方法进行的传质建模能够计算磷酸盐的摩尔浓度，从而与布洛芬的生理溶解性达到良好的匹配。这表明可以开发出避免与碳酸氢盐-CO2系统相关的技术难题的碳酸氢盐替代缓冲液。此外，通过将隔室药代动力学模型应用于先前在健康人志愿者进行的体内研究中针对这些悬浮液获得的血浆谱，来确定所测试的悬浮液的肠道溶解动力学。当在药代动力学研究中应用于健康人类志愿者时，碳酸氢盐中的体外溶出曲线与代表被测混悬液的体内肠道溶出动力​​学的曲线比较好。这表明了扩大生物豁免的可能潜力，使其包括BCS IIa类化合物。当在药代动力学研究中应用于健康人类志愿者时，碳酸氢盐中的体外溶出曲线与代表被测悬浮液的体内肠道溶出动力​​学的曲线比较好。这表明了扩大生物豁免的可能潜力，使其包括BCS IIa类化合物。当在药代动力学研究中应用于健康人类志愿者时，碳酸氢盐中的体外溶出曲线与代表被测悬浮液的体内肠道溶出动力​​学的曲线比较好。这表明了扩大生物豁免的可能潜力，使其包括BCS IIa类化合物。