Early weight loss (rapid response [RR]) is associated with better outcomes in adults. Less is known about RR in children enrolled in weight‐loss treatment. The aim of the current study was to establish an RR weight‐loss threshold following 4 weeks of pediatric obesity treatment and identify characteristics associated with achieving RR. One hundred thirty‐seven children aged 8 to 12 with overweight/obesity and parents participated in 6 months of family‐based or parent‐based treatment. Receiver operating characteristic curves evaluated how weight loss at week 4 related to decreases of 5% at posttreatment and 10% at 6‐ and 18‐month follow‐ups of standardized body mass index (BMIz), percentage distance of a child's BMI from the median BMI for sex and age, and percentage above the 95th percentile. Weight loss of 2.4% to 3.4% at week 4 predicted 5% change at posttreatment (AUC's = .68‐.75; P's ≤ .002) and 10% change at 6‐month follow‐up (AUC's = .63‐.70; P's ≤ .02). No model was significant at 18‐month follow‐up. Amount of parent weight (lbs) change at week 4 was associated with child achieving RR. Males and Non‐Hispanic Whites were more likely to achieve RR. This threshold could be used to mark early significant progress and guide clinical evaluations of treatment response to paediatric obesity treatment.

中文翻译：

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定义和识别对儿童肥胖治疗快速反应的预测因子。

早期减肥（快速反应[RR]）与成人预后更好相关。参加减肥治疗的儿童对RR的了解较少。本研究的目的是在小儿肥胖治疗4周后建立RR减肥阈值，并确定与实现RR相关的特征。137名8-12岁的超重/肥胖儿童和父母参加了为期6个月的家庭或父母治疗。接收者的操作特征曲线评估了标准体重指数（BMIz），儿童BMI与中位数的百分比距离，治疗后第4周的体重减轻与治疗后5％的下降以及在6个月和18个月的随访中10％的下降如何相关性别和年龄的BMI，以及高于95％的百分比。体重减轻2.4％至3。P '在6个月的随访小号≤0.002）和10％的变化（AUC的= 0.63-0.70; P的≤0.02）。在18个月的随访中，没有模型是有意义的。第4周父母体重（lbs）的变化与孩子达到RR有关。男性和非西班牙裔白人更可能达到RR。该阈值可用于标记早期的重大进展，并指导对小儿肥胖症治疗反应的临床评估。