Objective: Few studies have investigated haem oxygenase-1 gene (HMOX1) promoter polymorphism in microvascular angina (MVA).Materials and methods: HMOX1 promoter (GT)n repeats were examined in healthy controls (N = 220) and MVA subjects (N = 181).Results: The distribution of genotype of SS, SL and LL were significantly different in MVA (17%, 51%, 33%) vs. normal controls (35%, 46%, 20%) (p < 0.001, S allele: ≤30 repeats, L allele: >30 repeats). In multivariate analysis, carrier of L allele (odds ratio 2.772, p < 0.001) was a significant predictor for the diagnosis of MVA.Conclusions: Subjects with MVA had longer HMOX1 promoter (GT)n repeats than the healthy controls. Trial registration number: NCT01198730 at https://clinicaltrials.gov.

中文翻译：

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患有微血管性心绞痛的受试者在血红素加氧酶-1基因启动子中具有较长的GT重复多态性。

目的：很少有研究研究微血管性心绞痛（MVA）中的血红素加氧酶-1基因（HMOX1）启动子多态性。材料与方法：在健康对照组（N = 220）和MVA受试者（N = 181）。结果：MVA（17％，51％，33％）的SS，SL和LL基因型分布与正常对照组（35％，46％，20％）显着不同（p <0.001，S等位基因：≤30个重复，L个等位基因：> 30个重复）。在多变量分析中，L等位基因的携带者（比值2.772，p <0.001）是诊断MVA的重要预测指标。结论：MVA患者的HMOX1启动子（GT）n重复序列比健康对照更长。试用注册号：NCT01198730，网址为https://clinicaltrials.gov。