Background: Previous studies have demonstrated the diagnostic value of glucose transporter 1 (GLUT-1) to distinguish malignant mesothelioma (MM) from reactive mesothelial cells (RMC), but the results are inconsistent. The purpose of this meta-analysis is to investigate the diagnostic accuracy of GLUT-1 in distinguishing MM from RMC.Methods: A systematical search was conducted until May 2019 in PubMed, Medline, Embase and the Cochrane Library. The revised tool for the quality assessment of diagnostic accuracy studies (QUADAS-2) was used to assess the quality of the eligible studies. The Stata15 and Review Manager5.3 software programmes were used to perform the meta-analysis.Results: A total of 24 studies, including 969 MM patients and 1080 RMC individuals were explored in the meta-analysis. The summary assessments revealed that the pooled sensitivity was 0.73 (95% CI, 0.62-0.81) and the pooled specificity was 0.95 (95% CI, 0.91-0.98). The area under the summary ROC curve (AUC) was 0.93 (95% CI: 0.91-0.95).Conclusions: GLUT-1 is highly accurate to distinguish MM from RMC.

中文翻译：

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GLUT-1在区分恶性间皮瘤和反应性间皮细胞中的诊断价值：一项荟萃分析。

背景：以前的研究表明葡萄糖转运蛋白1（GLUT-1）的诊断价值，以区分恶性间皮瘤（MM）与反应性间皮细胞（RMC），但结果不一致。这项荟萃分析的目的是研究GLUT-1在区分MM和RMC中的诊断准确性。方法：一直进行到2019年5月，在PubMed，Medline，Embase和Cochrane图书馆进行系统搜索。经修订的诊断准确性研究质量评估工具（QUADAS-2）用于评估合格研究的质量。结果：在荟萃分析中共研究了24项研究，包括969例MM患者和1080例RMC患者。简要评估显示，合并的敏感性为0.73（95％CI，0.62-0.81），合并的特异性为0.95（95％CI，0.91-0.98）。摘要ROC曲线下面积（AUC）为0.93（95％CI：0.91-0.95）。结论：GLUT-1能够高度准确地区分MM和RMC。