Background: The purpose of this meta-analysis was to evaluate the relationship between elevated cardiac troponin pre-transcatheter aortic valve replacement (TAVR) and long-term all-cause mortality.Methods: Prospective studies with the endpoint of all-cause mortality were included. We primarily used the fixed-effect model weighted by inverse variance. Meta-regression and subgroup analyses were conducted to explore the potential sources of heterogeneity by specified study characteristics.Results: Seven prospective studies comprising of 3049 subjects were included in our meta-analysis. Pre-procedural elevated cardiac troponin was associated with increased risk of long-term mortality post TAVR [hazard ratio (HR) 2.25, 95% CI 1.83-2.78, p = 0.000, I2 = 30.3%, p for heterogeneity 0.197]. In addition, subgroup analyses have shown that the group with an younger age (<82 y) seemed to have a higher risk of all-cause mortality than the group with older age (≥82 y) [HR 4.08 (2.41 to 6.89) VS 2.01 (1.60 to 2.53), p = 0.016 for subgroup difference].Conclusions: Pre-procedural elevated cardiac troponin was associated with increased long-term all-cause mortality in patients undergoing TAVR.

中文翻译：

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术前心脏肌钙蛋白升高可预测经导管主动脉瓣置换后长期全因死亡的风险：一项前瞻性研究的荟萃分析。

背景：本荟萃分析的目的是评估心脏肌钙蛋白在经导管前主动脉瓣置换术（TAVR）升高与长期全因死亡率之间的关系。 。我们主要使用通过反方差加权的固定效应模型。进行荟萃回归和亚组分析，以通过特定的研究特征探索异质性的潜在来源。结果：我们的荟萃分析包括七项前瞻性研究，其中包括3049名受试者。术前心脏肌钙蛋白升高与TAVR术后长期死亡风险增加相关[危险比（HR）2.25，95％CI 1.83-2.78，p = 0.000，I2 = 30.3％，异质性p = 0.197]。此外，