Despite the excellent efficacy and low toxicity of photoresponse therapy, which has attracted considerable attention for use in non-small cell lung cancer (NSCLC) therapy, unsatisfactory cellular permeability, and instability, both in vitro and in vivo have limited further clinical applications of indole cyanine photosensitizers. Here, we explore the supramolecular self-assembly of a 'hyalurosome' that is mediated by calcium phosphate nanonuclei. Through hyaluronate-mediated CD44 targeting, the constructed hyalurosome specifically delivers ICG into NSCLC cells and then induces severe hyperthermia accompanied by the generation of singlet oxygen upon photoirradiation. In contrast to the action of the native form, indocyanine green encapsulated in a hyalurosome showed significantly increased cellular endocytosis and inhibited cell proliferation both in vitro and in vivo. Our study indicated that this hyalurosome is a promising candidate for the targeted delivery of photosensitizers, which may be useful in NSCLC therapy.

中文翻译：

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非小细胞肺癌中靶向光热疗法的杂交“透明质体”的超分子自组装。

尽管光响应疗法具有出色的疗效和低毒性，但在非小细胞肺癌（NSCLC）治疗中使用引起了广泛关注，细胞通透性不佳且不稳定，在体外和体内都限制了吲哚的进一步临床应用花青光敏剂。在这里，我们探索由磷酸钙纳米核介导的“透明质体”的超分子自组装。通过透明质酸介导的CD44靶向，构建的透明质体将ICG特异性地递送至NSCLC细胞，然后诱导严重的体温过高，并伴随光照射产生单线态氧。与原生形式的作用相反，封装在透明质酸中的吲哚菁绿在体外和体内均表现出明显的细胞内吞作用并抑制细胞增殖。我们的研究表明，这种透明质酸是光敏剂靶向递送的有希望的候选者，这可能在NSCLC治疗中有用。