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Multi-target approaches to CNS repair: olfactory mucosa-derived cells and heparan sulfates.
Nature Reviews Neurology ( IF 28.2 ) Pub Date : 2020-02-25 , DOI: 10.1038/s41582-020-0311-0 Susan L Lindsay 1 , George A McCanney 1 , Alice G Willison 1 , Susan C Barnett 1
Nature Reviews Neurology ( IF 28.2 ) Pub Date : 2020-02-25 , DOI: 10.1038/s41582-020-0311-0 Susan L Lindsay 1 , George A McCanney 1 , Alice G Willison 1 , Susan C Barnett 1
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Spinal cord injury (SCI) remains one of the biggest challenges in the development of neuroregenerative therapeutics. Cell transplantation is one of numerous experimental strategies that have been identified and tested for efficacy at both preclinical and clinical levels in recent years. In this Review, we briefly discuss the state of human olfactory cell transplantation as a therapy, considering both its current clinical status and its limitations. Furthermore, we introduce a mesenchymal stromal cell derived from human olfactory tissue, which has the potential to induce multifaceted reparative effects in the environment within and surrounding the lesion. We argue that no single therapy will be sufficient to treat SCI effectively and that a combination of cell-based, rehabilitation and pharmaceutical interventions is the most promising approach to aid repair. For this reason, we also introduce a novel pharmaceutical strategy based on modifying the activity of heparan sulfate, an important regulator of a wide range of biological cell functions. The multi-target approach that is exemplified by these types of strategies will probably be necessary to optimize SCI treatment.
中文翻译：
中枢神经系统修复的多靶点方法：嗅粘膜衍生细胞和硫酸乙酰肝素。
脊髓损伤 (SCI) 仍然是神经再生疗法发展中的最大挑战之一。细胞移植是近年来在临床前和临床水平上已经确定和测试功效的众多实验策略之一。在这篇综述中，我们简要讨论了人类嗅觉细胞移植作为一种疗法的状态，同时考虑到其目前的临床状况和局限性。此外，我们引入了一种源自人类嗅觉组织的间充质基质细胞，它有可能在病变内部和周围的环境中诱导多方面的修复作用。我们认为，没有一种单一的疗法足以有效治疗 SCI，并且基于细胞的组合，康复和药物干预是最有希望的辅助修复方法。出于这个原因，我们还介绍了一种基于改变硫酸乙酰肝素活性的新药物策略，硫酸乙酰肝素是多种生物细胞功能的重要调节剂。以这些类型的策略为例的多目标方法可能是优化 SCI 治疗所必需的。
更新日期：2020-02-25
中文翻译：
中枢神经系统修复的多靶点方法：嗅粘膜衍生细胞和硫酸乙酰肝素。
脊髓损伤 (SCI) 仍然是神经再生疗法发展中的最大挑战之一。细胞移植是近年来在临床前和临床水平上已经确定和测试功效的众多实验策略之一。在这篇综述中，我们简要讨论了人类嗅觉细胞移植作为一种疗法的状态，同时考虑到其目前的临床状况和局限性。此外，我们引入了一种源自人类嗅觉组织的间充质基质细胞，它有可能在病变内部和周围的环境中诱导多方面的修复作用。我们认为，没有一种单一的疗法足以有效治疗 SCI，并且基于细胞的组合，康复和药物干预是最有希望的辅助修复方法。出于这个原因，我们还介绍了一种基于改变硫酸乙酰肝素活性的新药物策略，硫酸乙酰肝素是多种生物细胞功能的重要调节剂。以这些类型的策略为例的多目标方法可能是优化 SCI 治疗所必需的。
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