Chemoresistance including intrinsic and acquired anticancer drug resistance continues to be a primary hindrance towards curative cancer treatment. Therefore, deciphering the underlying molecular mechanisms is of paramount importance required towards the overcoming of chemoresistance. Cumulative evidence revealed that long non-coding RNAs (lncRNAs) play a pivotal role in conferring anticancer drug resistance upon a broad spectrum of cancers. Hence, numerous lncRNAs are recognized as novel biomarkers and therapeutic targets in the diagnosis and treatment of malignancies, which urges us to comprehensively delineate the critical functions of lncRNAs in chemoresistance. In this respect, we herein succinctly elucidate the molecular mechanisms by which lncRNAs modulate their downstream targets to mediate cancer chemoresistance. Therefore, the current review may provide a significant basis for the future conquering of chemoresistance via targeting lncRNAs in cancer therapeutics.

包括内在和获得性抗癌药耐药性在内的化学耐药性仍然是治愈性癌症治疗的主要障碍。因此，破解潜在的分子机制对于克服化学抗性至关重要。累积证据表明，长的非编码RNA（lncRNA）在赋予多种癌症抗癌药耐药性中起着关键作用。因此，在恶性肿瘤的诊断和治疗中，许多lncRNA被公认为是新的生物标志物和治疗靶标，这促使我们全面描述lncRNA在化学抗性中的关键功能。在这方面，我们在本文中简要阐明了lncRNA调节其下游靶标以介导癌症化学抗性的分子机制。因此，