Iodine‐catalyzed ultrasound‐assisted construction of pyridines and their glutamine synthetase molecular docking,Journal of the Chinese Chemical Society

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Iodine‐catalyzed ultrasound‐assisted construction of pyridines and their glutamine synthetase molecular docking
Journal of the Chinese Chemical Society ( IF 1.6 ) Pub Date : 2020-02-25 , DOI: 10.1002/jccs.201900389
Ramakanth Pagadala ₁ , Venkatesan Kasi ₁ , Shyam Perugu ₂

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Iodine‐promoted facile protocol is designed for the production of pyridines at room temperature under ultrasound irradiation. Eleven pyridine derivatives in excellent yields (91–97%) are synthesized with 2 hr reaction time. Additional advantage of the proposed ultrasound‐assisted eco‐friendly, cost‐effective protocol is easy separation of product, and our in silico studies show good binding affinity toward binding and made strong hydrogen interactions.

中文翻译：

碘催化的吡啶吡啶及其谷氨酰胺合成酶分子对接的超声构建

碘促进的操作规程旨在用于在室温下超声辐射下生产吡啶。在2小时的反应时间内可以合成11种吡啶衍生物，产率很高（91–97％）。拟议的超声辅助的生态友好，经济高效的方案的另一个优势是易于分离产品，我们的计算机研究表明对结合具有良好的结合亲和力，并具有很强的氢相互作用。

更新日期：2020-02-25

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