FLIP(L): the pseudo‐caspase,The FEBS Journal

当前位置： X-MOL 学术 › FEBS J. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

FLIP(L): the pseudo‐caspase
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-02-24 , DOI: 10.1111/febs.15260
Peter Smyth ₁ , Tamas Sessler ₁ , Christopher J. Scott ₁ , Daniel B. Longley ₁

Affiliation

Possessing structural homology with their active enzyme counterparts but lacking catalytic activity, pseudoenzymes have been identified for all major enzyme groups. Caspases are a family of cysteine‐dependent aspartate‐directed proteases that play essential roles in regulating cell death and inflammation. Here, we discuss the only human pseudo‐caspase, FLIP(L), a paralog of the apoptosis‐initiating caspases, caspase‐8 and caspase‐10. FLIP(L) has been shown to play a key role in regulating the processing and activity of caspase‐8, thereby modulating apoptotic signaling mediated by death receptors (such as TRAIL‐R1/R2), TNF receptor‐1 (TNFR1), and Toll‐like receptors. In this review, these canonical roles of FLIP(L) are discussed. Additionally, a range of nonclassical pseudoenzyme roles are described, in which FLIP(L) functions independently of caspase‐8. These nonclassical pseudoenzyme functions enable FLIP(L) to play key roles in the regulation of a wide range of biological processes beyond its canonical roles as a modulator of cell death.

中文翻译：

FLIP（L）：准胱天蛋白酶

具有与它们的活性酶对应物的结构同源性，但缺乏催化活性，已鉴定出所有主要酶基团的假酶。胱天蛋白酶是半胱氨酸依赖性天冬氨酸定向蛋白酶的家族，在调节细胞死亡和炎症中起重要作用。在这里，我们讨论了唯一的人类假性半胱天冬酶FLIP（L），它是启动凋亡的半胱天冬酶caspase-8和caspase-10的旁系同源物。已证明FLIP（L）在调节caspase-8的加工和活性中起关键作用，从而调节由死亡受体（如TRAIL-R1 / R2），TNF受体-1（TNFR1）和收费型受体。在这篇综述中，讨论了FLIP（L）的这些规范作用。此外，还介绍了一系列非经典假酶作用，其中FLIP（L）的功能独立于caspase-8。这些非经典的伪酶功能使FLIP（L）在调节广泛的生物过程中发挥关键作用，而不仅仅是作为细胞死亡的调节剂。

更新日期：2020-02-24

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文