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Continuous-Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase-Oxovanadium Cocatalysis
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-03-17 , DOI: 10.1002/ejoc.202000186
Koichi Higashio 1 , Satoko Katsuragi 1 , Dhiman Kundu 1 , Niklas Adebar 2 , Carmen Plass 2 , Franziska Kühn 2 , Harald Gröger 2 , Shuji Akai 1
Affiliation  

A continuous-flow dynamic kinetic resolution of racemic secondary alcohols was carried out using a single column reactor packed with a mixture of immobilized lipase and an immobilized oxovanadium species, VMPS4. As a result, optically pure esters were produced in 88–92 % yields. Problems encountered in this study were overcome by using fillers that efficiently

中文翻译:

脂肪酶-氧钒助催化连续流动动态动力学拆分外消旋醇

外消旋仲醇的连续流动动态动力学拆分使用填充有固定化脂肪酶和固定化氧钒物质 VMPS4 的混合物的单柱反应器进行。结果,光学纯酯的产率为 88-92%。本研究中遇到的问题通过使用有效的填料来克服
更新日期:2020-03-17
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