Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine.,Leukemia

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Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine.
Leukemia ( IF 12.8 ) Pub Date : 2020-02-25 , DOI: 10.1038/s41375-020-0772-6
S Pützer _{1,

2,

3} , L Varghese _{1,

2,

3} , J von Jan _{1,

2,

3} , T Braun _{1,

2,

3} , A K Giri ₄ , P Mayer _{1,

2,

3} , N Riet _{1,

3} , S Timonen _{4,

5,

6,

7} , S Oberbeck _{1,

2,

3} , H Kuusanmäki _{4,

5,

6,

7} , S Mustjoki _{5,

6,

7} , M-H Stern ₈ , T Aittokallio _{4,

9} , S Newrzela ₁₀ , A Schrader _{1,

2,

3} , M Herling _{1,

2,

3}

Affiliation

Department of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf (CIO ABCD), University of Cologne (UoC), Cologne, Germany.
Excellence Cluster for Cellular Stress Response and Aging-Associated Diseases (CECAD), UoC, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), UoC, Cologne, Germany.
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Hematology Research Unit Helsinki, Helsinki University Hospital, Comprehensive Cancer Center, Helsinki, Finland.
Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
INSERM U830, Institut Curie, PSL Research University, Paris, 75013, France.
Department of Mathematics and Statistics, University of Turku, Turku, Finland.
Senckenberg Institute of Pathology, Goethe-University, Frankfurt am Main, Germany.