Muscle wasting, resulting from aging or pathological conditions, leads to reduced quality of life, increased morbidity, and increased mortality. Much research effort has been focused on the development of exercise mimetics to prevent muscle atrophy and weakness. In this study, we identified indoprofen from a screen for peroxisome proliferator‐activated receptor γ coactivator α (PGC‐1α) inducers and report its potential as a drug for muscle wasting.

中文翻译：

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吲哚洛芬通过激活 PDK1/AKT 通路防止老年小鼠肌肉萎缩。

由衰老或病理状况引起的肌肉萎缩会导致生活质量下降、发病率增加和死亡率增加。许多研究工作都集中在开发运动模拟物以防止肌肉萎缩和虚弱。在这项研究中，我们从过氧化物酶体增殖物激活受体 γ 辅激活因子 α (PGC-1α) 诱导剂的筛选中鉴定出吲哚洛芬，并报告了其作为肌肉萎缩药物的潜力。