Cannabis legalization and commercialization has resulted in novel alternative cannabis products on the market, including edible and vaporized cannabis, which may appeal to youth with psychiatric problems. Psychiatric comorbidity in adolescent use and poly-use (i.e., use of >2 products) of combustible, edible, and vaporized cannabis products has largely gone uninvestigated. This 2015 cross-sectional survey of Los Angeles, California area adolescents (Mage = 16.1, N = 3177) characterized associations of various psychiatric problems with use and poly-use of combustible, edible, and vaporized cannabis. Exposure variables included past 30-day non-cannabis substance use (alcohol, e-cigarettes, combustible cigarettes, and nonmedical prescription opioid and stimulant use; yes/no), and psychiatric problems including past-week depressive symptom frequency, past 6-month ADHD symptom and conduct problem frequency, anhedonia, and five dimensions of impulsivity (sensation seeking, perseverance, lack of premeditation, positive urgency, and negative urgency). Outcome variables included past 30-day use (yes/no) of combustible, edible, and vaporized cannabis, independently, and number of cannabis products used (single, dual-use, poly-use). Results showed that all forms of non-cannabis substance use (ORs range: 13.7-36.1) and all psychiatric symptoms and traits (ORs in SD units range: 1.1-2.1) were positively associated with combustible, edible, and vaporized cannabis product use. The magnitude of comorbidity did not significantly differ by cannabis product type used in most cases. Psychiatric comorbidity was typically stronger in poly-product than single-product cannabis use and greater for externalizing-type than internalizing-type psychiatric problems. Practitioners, policy makers, and scientists should be aware that pervasive psychiatric comorbidity may be observed across the spectrum of cannabis product use among adolescents, particularly poly-product users.

中文翻译：

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青少年使用和多次使用可燃、汽化和食用大麻产品的精神共病。

大麻合法化和商业化导致市场上出现了新型替代大麻产品，包括食用大麻和汽化大麻，这可能会吸引有精神问题的年轻人。青少年使用和多次使用（即使用> 2种产品）可燃、可食用和汽化大麻产品导致的精神共病基本上没有得到调查。这项 2015 年对加利福尼亚州洛杉矶地区青少年（Mage = 16.1，N = 3177）的横断面调查描述了各种精神问题与使用和多次使用可燃、可食用和汽化大麻之间的关联。暴露变量包括过去 30 天的非大麻物质使用（酒精、电子烟、可燃香烟以及非医疗处方阿片类药物和兴奋剂使用；是/否），以及精神问题，包括过去一周抑郁症状频率、过去 6 个月ADHD 症状和行为问题频率、快感缺乏和冲动的五个维度（寻求感觉、毅力、缺乏预谋、积极紧迫感和消极紧迫感）。结果变量包括过去 30 天独立使用可燃、可食用和汽化大麻（是/否），以及使用的大麻产品数量（单用、双用、多用）。结果显示，所有形式的非大麻物质使用（OR 范围：13.7-36.1）以及所有精神症状和特征（SD 单位范围内的 OR：1.1-2.1）均与可燃、可食用和汽化大麻产品的使用呈正相关。在大多数情况下，合并症的严重程度因使用的大麻产品类型没有显着差异。多产品大麻使用中的精神共病通常比单一产品大麻使用更强，外化型精神问题比内化型精神问题更大。从业者、政策制定者和科学家应该意识到，在青少年，特别是多产品使用者中，在大麻产品使用的各个方面都可能观察到普遍存在的精神共病。