Stroke is a considerable cause of mortality and the leading cause of neurological disability, with post-stroke sequelae negatively impacting long-term mental and physical health.¹ Despite a high prevalence and growing incidence, current stroke treatments are limited to reperfusion strategies that, though effective in some patients, are not widely applicable. Lack of alternative stroke treatments is due to a number of reasons, one of which is an under-appreciation of the role that co-morbidities play in stroke etiology and prognosis.² It is clear that pre-existing conditions, often with inflammatory pathogeneses, are major determinants of stroke-induced damage in both humans and rodent models. Indeed, obesity,^3–5 infection,^6,7 atherosclerosis,⁸ and old age^9,10 can all negatively affect ischemic brain damage and overall recovery in animal models. Although there is an emerging focus on stroke co-morbidities, the common oral disease periodontitis (PD) is under-studied in this respect, despite being frequently associated with increased risk of ischemic stroke in humans.^11–20

中文翻译：

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结扎性牙周炎可诱发全身性炎症，但不会改变小鼠中风后的急性结局

中风是导致死亡的重要原因，也是神经系统残疾的主要原因，中风后遗症会对长期的身心健康产生负面影响。¹尽管患病率很高且发病率不断增加，但目前的中风治疗仅限于再灌注策略，尽管对某些患者有效，但并未广泛应用。缺乏中风替代疗法的原因很多，其中之一是对合并症在中风病因和预后中所起的作用的认识不足。²很明显，在人类和啮齿动物模型中，通常带有炎症性病原体的既往条件是中风诱发损害的主要决定因素。确实，肥胖，^3-5感染，^6.78岁的动脉粥样硬化^患者和^9,10岁的老年人都可以对缺血性脑损伤和动物模型的整体恢复产生负面影响。尽管人们越来越关注中风并发症，但是尽管这经常与人类缺血性中风的风险增加相关，但在这方面对常见的口腔疾病牙周炎（PD）的研究仍不足。^11–20