Epidemiological research has shown there to be a strong relationship between preconceptional, prenatal, birth and early-life factors and lifelong health. The Lifelines NEXT is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease in a four-generation design. It is embedded within the Lifelines cohort study, a prospective three-generation population-based cohort study recording the health and health-related aspects of 167,729 individuals living in Northern Netherlands. In Lifelines NEXT we aim to include 1500 pregnant Lifelines participants and intensively follow them, their partners and their children until at least 1 year after birth. Longer-term follow-up of physical and psychological health will then be embedded following Lifelines procedures. During the Lifelines NEXT study period biomaterials-including maternal and neonatal (cord) blood, placental tissue, feces, breast milk, nasal swabs and urine-will be collected from the mother and child at 10 time points. We will also collect data on medical, social, lifestyle and environmental factors via questionnaires at 14 different time points and continuous data via connected devices. The extensive collection of different (bio)materials from mother and child during pregnancy and afterwards will provide the means to relate environmental factors including maternal and neonatal microbiome composition) to (epi)genetics, health and developmental outcomes. The nesting of the study within Lifelines enables us to include preconceptional transgenerational data and can be used to identify other extended families within the cohort.

中文翻译：

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下一步生命线：前瞻性出生队列，将下一代添加到三代生命线队列研究中。


流行病学研究表明，孕前、产前、出生和生命早期因素与终生健康之间存在密切关系。 Lifelines NEXT 是一个出生队列，旨在以四代设计研究内在和外在决定因素对健康和疾病的影响。它嵌入在生命线队列研究中，这是一项基于三代人群的前瞻性队列研究，记录了居住在荷兰北部的 167,729 名个体的健康和健康相关方面。在 Lifelines NEXT 中，我们的目标是纳入 1500 名怀孕的 Lifelines 参与者，并密切关注他们、他们的伴侣和孩子，直到出生后至少 1 年。生命线程序之后将纳入对身体和心理健康的长期随访。在 Lifelines NEXT 研究期间，将从母亲和孩子的 10 个时间点收集生物材料，包括母体和新生儿（脐带）血、胎盘组织、粪便、母乳、鼻拭子和尿液。我们还将通过 14 个不同时间点的问卷调查和通过连接设备的连续数据收集有关医疗、社会、生活方式和环境因素的数据。在怀孕期间和怀孕后广泛收集母亲和儿童的不同（生物）材料将提供将环境因素（包括孕产妇和新生儿微生物组组成）与（表观）遗传学、健康和发育结果联系起来的方法。该研究嵌套在生命线中，使我们能够纳入孕前跨代数据，并可用于识别队列中的其他大家庭。