Recent Advances and Perspectives in the Synthesis and Applications of Tetrahydrocarbazol‐4‐ones†,Chinese Journal of Chemistry

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Recent Advances and Perspectives in the Synthesis and Applications of Tetrahydrocarbazol‐4‐ones†
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-02-25 , DOI: 10.1002/cjoc.202000029
Muhammad Usman ₁ , Xu‐Dong Hu ₁ , Wen‐Bo Liu ₁

Affiliation

Tetrahydrocarbazol‐4‐one represents a prevalent framework of numerous natural products and pharmaceuticals. This review summaries the recent synthetic progresses of this core structure, including Fischer indolization, oxidative and reductive coupling, α‐arylative cyclization by means of transition‐ metal catalysis or under metal‐free conditions, and other methods. The recently emerged enantioselective catalytic methods of tetrahydrocarbazol‐4‐ ones are also described. The mechanistic insights and applications of these strategies as a key step in the total (formal) synthesis of complex alkaloids are highlighted as well.

中文翻译：

四氢咔唑-4-酮的合成和应用的最新进展和前景†

四氢咔唑-4-酮代表了众多天然产物和药物的普遍框架。该综述总结了该核心结构的最新合成进展，包括费歇尔吲哚化，氧化和还原偶联，通过过渡金属催化或在无金属条件下的α-芳基环化以及其他方法。还介绍了最近出现的四氢咔唑-4-对映体的对映选择性催化方法。这些策略的机械学见解和应用作为复杂生物碱全（正式）合成中的关键步骤也得到了强调。

更新日期：2020-02-25

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