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Temporal trends of suspect- and target-per/polyfluoroalkyl substances (PFAS), extractable organic fluorine (EOF) and total fluorine (TF) in pooled serum from first-time mothers in Uppsala, Sweden, 1996-2017.
Environmental Science: Processes & Impacts ( IF 4.3 ) Pub Date : 2020-04-29 , DOI: 10.1039/c9em00502a
Luc T Miaz 1 , Merle M Plassmann , Irina Gyllenhammar , Anders Bignert , Oskar Sandblom , Sanna Lignell , Anders Glynn , Jonathan P Benskin
Affiliation  

A combined method for quantitative analysis, along with suspect and non-target screening of per- and polyfluoroalkyl substances (PFAS) was developed using ultra-high pressure liquid chromatography-ultra-high resolution (Orbitrap) mass spectrometry. The method was applied together with measurements of total- and extractable organofluorine (TF and EOF, respectively), to pooled serum samples from 1996-2017 from first-time mothers living in the county of Uppsala, Sweden, some of which (i.e. 148 of 472 women sampled 1996-2012) were exposed to drinking water contaminated with perfluorohexane sulfonate (PFHxS) and other PFAS until mid-2012. Declining trends were observed for all target PFAS as well as TF, with homologue-dependent differences in year of onset of decline. Only 33% of samples displayed detectable EOF, and amongst these samples the percentage of EOF explained by target PFAS declined significantly (-3.5% per year) over the entire study period. This finding corroborates prior observations in Germany after the year 2000, and may reflect increasing exposure to novel PFAS which have not yet been identified. Suspect screening revealed the presence of perfluoro-4-ethylcyclohexanesulfonate (PFECHS), which displayed declining trends since the year 2000. Non-target time trend screening revealed 3 unidentified features with time trends matching PFHxS. These features require further investigation, but may represent contaminants which co-occurred with PFHxS in the contaminated drinking water.

中文翻译:

1996-2017年,瑞典乌普萨拉初生母亲的混合血清中可疑和目标/多氟烷基物质(PFAS),可萃取有机氟(EOF)和总氟(TF)的时间趋势。

使用超高压液相色谱-超高分辨率(Orbitrap)质谱技术开发了一种组合的定量分析方法,以及对全氟和多氟烷基物质(PFAS)的可疑和非目标筛选。将该方法与总氟和可萃取有机氟(分别为TF和EOF)的测量结果结合使用,收集了1996-2017年来自瑞典乌普萨拉县的首次母亲的血清样本,其中一些(即148例)直到2012年年中,有472名从1996年至2012年抽样的妇女)暴露于被全氟己烷磺酸盐(PFHxS)和其他PFAS污染的饮用水中。观察到所有目标PFAS和TF均呈下降趋势,在下降开始的年份中具有同源物依赖性差异。只有33%的样本显示可检测到的EOF,在这些样本中,由目标PFAS解释的EOF百分比在整个研究期内显着下降(每年-3.5%)。这一发现证实了2000年以后德国的先前观察结果,并且可能反映出对尚未确定的新型PFAS的暴露日益增加。可疑筛查发现存在全氟-4-乙基环己烷磺酸盐(PFECHS),自2000年以来呈下降趋势。非目标时间趋势筛查显示3个不确定特征,时间趋势与PFHxS相匹配。这些功能需要进一步研究,但可能代表受污染的饮用水中与PFHxS共同出现的污染物。这一发现证实了2000年以后德国的先前观察结果,并且可能反映出对尚未确定的新型PFAS的暴露日益增加。可疑筛查发现存在全氟-4-乙基环己烷磺酸盐(PFECHS),自2000年以来呈下降趋势。非目标时间趋势筛查显示3个不确定特征,时间趋势与PFHxS相匹配。这些功能需要进一步研究,但可能代表受污染的饮用水中与PFHxS共同出现的污染物。这一发现证实了2000年以后德国的先前观察结果,并且可能反映出对尚未确定的新型PFAS的暴露日益增加。可疑筛查发现存在全氟-4-乙基环己烷磺酸盐(PFECHS),自2000年以来呈下降趋势。非目标时间趋势筛查显示3个不确定特征,时间趋势与PFHxS相匹配。这些功能需要进一步研究,但可能代表受污染的饮用水中与PFHxS共同出现的污染物。非目标时间趋势筛选显示3个未识别特征,且时间趋势与PFHxS相匹配。这些功能需要进一步研究,但可能代表受污染的饮用水中与PFHxS共同出现的污染物。非目标时间趋势筛选显示3个未识别特征,且时间趋势与PFHxS相匹配。这些功能需要进一步研究,但可能代表受污染的饮用水中与PFHxS共同出现的污染物。
更新日期:2020-02-25
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