Fanconi Bickel Syndrome (FBS) is an autosomal recessive disease resulting from mutations in the SLC2A2 gene, encoding the GLUT2. FBS patients develop diabetes mellitus. Using non-integrating Sendai virus, we generated an induced pluripotent stem cell (iPSC) line, QBRIi007-A, carrying the c.613-7 T>G homozygous mutation in intron 5 of the SLC2A2 gene from a 19-year-old female with FBS and diabetes. The iPSC line was characterized for pluripotency, differentiation potential, genomic integrity, and genetic identity. This iPSC line provides a useful cell model to understand the role of GLUT2 in the disease development and to discover new drug candidates.

Fanconi Bickel 综合征 (FBS) 是一种常染色体隐性遗传病，由编码 GLUT2的SLC2A2基因突变引起。FBS 患者发展为糖尿病。使用非整合仙台病毒，我们生成了诱导多能干细胞 (iPSC) 系 QBRIi007-A，该系携带来自 19 岁女性的SLC2A2基因的内含子 5 中的 c.613-7 T > G纯合突变与 FBS 和糖尿病。iPSC 系的特征在于多能性、分化潜能、基因组完整性和遗传同一性。该 iPSC 系提供了一个有用的细胞模型来了解 GLUT2 在疾病发展中的作用并发现新的候选药物。