The Takotsubo syndrome (TTS) is characterized by acute transient left ventricular dysfunction in the absence of obstructive coronary lesions. An enhanced β-adrenergic signaling and higher sensitivity to catecholamine-induced-toxicity were identified as mechanisms associated with TTS. It is still elusive, whether TTS patients with recurrent events show similar underlying signaling pathomechanism. Induced pluripotent stem cell (iPSC)-lines were generated from skin fibroblasts of two independent female Takotsubo syndrome patients with a severe phenotype characterized by recurrent TTS events. For reprogramming, a non-integrative plasmid technique was used. All generated iPSCs maintained full pluripotency, genomic integrity, and spontaneous in vitro and in vivo differentiation capacity.

Takotsubo综合征（TTS）的特征是在没有梗阻性冠状动脉病变的情况下出现急性短暂性左心室功能障碍。增强的β-肾上腺素信号传导和对儿茶酚胺诱导的毒性更高的敏感性被确定为与TTS相关的机制。患有复发性事件的TTS患者是否显示出类似的潜在信号传导机制尚不清楚。诱导多能干细胞（iPSC）系由两名独立的女性Takotsubo综合征患者的皮肤成纤维细胞产生，这些患者的严重表型具有复发性TTS事件的特征。对于重编程，使用了非整合质粒技术。所有生成的iPSC都保持完全的多能性，基因组完整性以及自发的体外和体内分化能力。