The outer mitochondrial membrane protein VDAC interacts with the ER protein IP3R via chaperone Grp75 to form a molecular complex that couples mitochondria to the ER and contributes to functional mitochondria-ER contacts (MERCs), essential for efficient calcium (Ca2+) transfer. A new study by Liu et al. identifies the PD protein DJ-1 as a component of the IP3R-Grp75-VDAC complex. DJ-1 ablation impairs mitochondria-ER association and Ca2+ crosstalk, and impacts the stability of the trio.

中文翻译：

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三重奏变成了四重奏：DJ-1与IP3R-Grp75-VDAC复合体相互作用以控制ER-线粒体相互作用。

线粒体外膜蛋白VDAC通过分子伴侣Grp75与ER蛋白IP3R相互作用形成分子复合物，将线粒体与ER偶联并有助于功能性线粒体-ER接触（MERC），这对于有效的钙（Ca2 +）转移至关重要。Liu等人的一项新研究。确定PD蛋白DJ-1是IP3R-Grp75-VDAC复合物的组成部分。DJ-1切除会削弱线粒体-ER缔合和Ca2 +串扰，并影响三重奏的稳定性。