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ncEP: A Manually Curated Database for Experimentally Validated ncRNA-encoded Proteins or Peptides.
Journal of Molecular Biology ( IF 4.7 ) Pub Date : 2020-02-24 , DOI: 10.1016/j.jmb.2020.02.022
Haizhou Liu 1 , Xu Zhou 1 , Mengqin Yuan 1 , Shunheng Zhou 1 , Yu-E Huang 1 , Fei Hou 1 , Xiaofeng Song 1 , Lihong Wang 2 , Wei Jiang 1
Affiliation  

Non-coding RNAs (ncRNAs), such as lncRNAs, circRNAs and pri-miRNAs, play important roles in physiological and pathological processes. Recently, it was demonstrated that they could encode proteins or peptides. However, relevant information is scattered across numerous published papers, which is inconvenient for the exploration of ncRNA translation by researchers. In this study, we presented an ncEP database, which records the low-throughput experimentally validated (LTEV) proteins or peptides encoded by ncRNAs, from published papers. Collectively, ncEP contains 80 entries including 74 proteins or peptides, 22 lncRNAs, 11 circRNAs, 9 pri-miRNAs and 37 other ncRNAs across 18 species from more than 50 papers out of over 2,000 candidate papers. We have provided a user-friendly interface for users to search, browse, visualize, download and submit data. In summary, ncEP provides a relatively comprehensive repository of the LTEV proteins or peptides encoded by ncRNAs, and will enrich the knowledge for translation process. ncEP is freely available at http://www.jianglab.cn/ncEP/.

中文翻译:

ncEP:用于经过实验验证的ncRNA编码的蛋白质或肽的手动编制的数据库。

非编码RNA(ncRNA),例如lncRNA,circRNA和pri-miRNA,在生理和病理过程中起重要作用。最近,证明它们可以编码蛋白质或肽。但是,相关信息分散在许多发表的论文中,这对于研究人员探索ncRNA翻译不方便。在这项研究中,我们提供了一个ncEP数据库,该数据库记录了已发表论文中由ncRNA编码的低通量实验验证(LTEV)蛋白质或肽。ncEP总共包含80种条目,包括74种蛋白质或多肽,22种lncRNA,11种circRNA,9种pri-miRNA和9种pri-miRNA和18种其他ncRNA,涉及2,000多种候选论文中的50多种论文。我们提供了一个用户友好的界面,供用户搜索,浏览,可视化,下载和提交数据。总之,ncEP提供了由ncRNA编码的LTEV蛋白质或肽的相对全面的信息库,并将丰富翻译过程的知识。ncEP可从http://www.jianglab.cn/ncEP/免费获得。
更新日期:2020-02-24
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