3D bioprinting directly into injured sites in a surgical setting, intraoperative bioprinting (IOB), is an effective process, in which the defect information can be rapidly acquired and then repaired via bioprinting on a live subject. In patients needing tissue resection, debridement, traumatic reconstruction, or fracture repair, the ability to scan and bioprint immediately following surgical preparation of the defect site has great potential to improve the precision and efficiency of these procedures. In this opinion article, we provide the reader with current major limitations of IOB from engineering and clinical points of view, as well as possibilities of future translation of bioprinting technologies from bench to bedside, and expound our perspectives in the context of IOB of composite and vascularized tissues.

中文翻译：

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术中生物打印：在手术环境中修复组织和器官。


在手术环境中直接对受伤部位进行 3D 生物打印，即术中生物打印 (IOB)，是一种有效的过程，可以快速获取缺陷信息，然后通过对活体受试者进行生物打印来修复。对于需要组织切除、清创、创伤重建或骨折修复的患者，在缺损部位进行手术准备后立即进行扫描和生物打印的能力对于提高这些手术的精度和效率具有巨大的潜力。在这篇观点文章中，我们从工程和临床的角度为读者提供了当前 IOB 的主要局限性，以及未来生物打印技术从实验室到临床转化的可能性，并在复合材料和生物打印的 IOB 背景下阐述了我们的观点。血管化组织。