BACKGROUND Glycomer 631 and lactomer 9-1 are absorbable suture materials indicated for soft tissue approximation in non-infected wounds. Pigs are often used as surgical models in translational research; however, reports of tissue reactions to both suture materials in pigs are limited. The aim of this study was to assess clinical and histologic responses of skin incisions closed with a subcuticular technique using glycomer 631 and lactomer 9-1 in pigs. RESULTS Skin incisions on 17 pigs were closed with glycomer 631 and lactomer 9-1, and a clinical reactive score (CRS) including erythema, swelling, discharge and dehiscence was calculated on postoperative days 7 and 14. Subcuticular tissue reaction was assessed histologically on postoperative day 14 (the presence of extravascular neutrophils, macrophages, multinucleated giant cells, lymphocytes, fibroblasts, bacterial colonies and the overall severity of the inflammatory response to the suture material), and the cumulative score of the variables was calculated as an aggregate tissue irritation score (ATIS). Tissue samples were examined for suture extrusion and evaluated microbiologically. The clinical reactive score did not differ between the suture materials. Only one ATIS variable, namely the overall severity of the inflammatory response, was lower (p = 0.029) when glycomer 631 was used. Suture extrusion was found in 10/17 of the incisions closed by glycomer 631 and in 7/13 of the incisions closed by lactomer 9-1. Trueperella pyogenes was isolated from the skin and from the area of tissue reaction in six pigs. CONCLUSIONS No difference in CRS between the suture materials was observed, and thus both materials may be used for the subcuticular technique in pigs. Glycomer 631 induced less tissue reaction only in terms of the overall severity of the inflammatory response. Suture extrusion was observed in more than 50% of incisions regardless of the suture material, possibly due to a large amount of suture material in the wound. Trueperella pyogenes was the only pathogen isolated from the tissue surrounding the suture material.

中文翻译：

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使用表皮下技术在猪中用糖蛋白631和内酯9-1封闭的皮肤切口的临床和组织学反应。

背景技术甘考默（Glycomer）631和内酯9-1是可吸收的缝合线材料，可用于未感染伤口中的软组织近似。猪经常被用作转化研究的外科模型。但是，关于猪中两种缝合线材料的组织反应的报道有限。这项研究的目的是评估在猪皮下使用糖蛋白631和内酯9-1用皮下技术封闭的皮肤切口的临床和组织学反应。结果17只猪的皮肤切口被糖蛋白631和内酰胺9-1封闭，并在术后第7和14天计算出包括红斑，肿胀，分泌物和裂开的临床反应评分（CRS）。第14天（血管外中性粒细胞，巨噬细胞，多核巨细胞，淋巴细胞的存在，成纤维细胞，细菌菌落和对缝线材料的炎症反应的总体严重程度），以及变量的累积得分，计算为总的组织刺激得分（ATIS）。检查组织样品的缝合线挤压并进行微生物学评估。缝合材料之间的临床反应评分没有差异。当使用糖聚物631时，只有一个ATIS变量，即炎症反应的总体严重程度较低（p = 0.029）。在由糖聚物631封闭的切口的10/17和由内酯9-1封闭的切口的7/13中发现缝合线挤出。从6只猪的皮肤和组织反应区域分离出化脓性疟原虫。结论在缝合材料之间未观察到CRS的差异，因此，这两种材料均可用于猪的皮下技术。仅就炎症反应的整体严重性而言，Glycomer 631诱导的组织反应较少。无论使用何种缝合材料，都在超过50％的切口中观察到缝合线挤压，这可能是由于伤口中的缝合线材料很多。化脓假单胞菌是从缝合材料周围组织中分离出的唯一病原体。