BACKGROUND Measurement of sputum is frequently used to define airway inflammatory subtypes. The venous blood cell is a reliable and simple biomarker, may be used as an alternative procedure to reflect the subtypes. For the aim of verifying the hypothesis that venous blood cell can quantify sputum inflammatory cell to access the airway subtypes in chronic obstructive pulmonary disease of acute exacerbations (AECOPD) and to ascertain the accuracy of the blood cell biomarker. METHODS This study evaluated 287 patients with COPD exacerbations and all four tests were performed on the same day, which are lung function test, bronchodilator reversibility test, sputum cell analysis and blood routine examination. RESULTS There was a correlation between sputum eosinophils and blood eosinophils, blood cells derived ratios. There was a weaker relationship to neutrophils between sputum and blood. Sputum neutrophils had not any association with neutrophil/macrophage ratio (NMR) and eosinophil/lymphocyte ratio (ELR) in blood. Blood eosinophils percentage was predictive for eosinophilic COPD exacerbations with an area under the curve (AUC) of 0.672 (p = 0.012). The optimum cutpoint for blood eosinophils percentage was 0.55%. Blood eosinophils absolute count was also predictive sputum eosinophilia at 0.35 × 109/L (AUC = 0.626, p = 0.025). ELR, eosinophil/monocyte ratio (EMR) and eosinophil/neutrophil ratio (ENR) in blood were higher in COPD exacerbations with mixed granulocytic and eosinophilic subtypes. CONCLUSION Eosinophils/neutrophils count parameters were relationship between blood and sputum. Eosinophils in blood and the ratios (ENR, EMR and ELR) may be utilized to assess eosinophilic airway inflammation in COPD exacerbations. Due to weak relationship and poor predictive ability, more researches should be required.

中文翻译：

---

血细胞用于COPD恶化中气道炎症表型的分化。

背景技术痰的测量经常用于定义气道炎性亚型。静脉血细胞是可靠且简单的生物标志物，可以用作反映亚型的替代方法。为了验证这一假设，即静脉血细胞可以量化痰炎性细胞进入急性加重期慢性阻塞性肺疾病（AECOPD）的气道亚型，并确定血细胞生物标志物的准确性。方法该研究评估了287例COPD恶化患者，并在同一天进行了全部四个检查，分别是肺功能检查，支气管扩张剂可逆性检查，痰细胞分析和血液常规检查。结果痰中嗜酸性粒细胞与血嗜酸性粒细胞，血细胞来源比率之间存在相关性。痰液与血液之间的中性粒细胞关系较弱。痰中性粒细胞与血液中的中性粒细胞/巨噬细胞比例（NMR）和嗜酸性粒细胞/淋巴细胞比例（ELR）没有任何关联。血液中嗜酸性粒细胞百分数可预测嗜酸性COPD恶化，曲线下面积（AUC）为0.672（p = 0.012）。血液嗜酸性粒细胞百分比的最佳临界点为0.55％。血嗜酸性粒细胞绝对计数也可预测痰嗜酸性粒细胞增多，为0.35×109 / L（AUC = 0.626，p = 0.025）。伴有粒细胞和嗜酸性粒细胞亚型的COPD急性加重时，血液中的ELR，嗜酸性粒细胞/单核细胞比率（EMR）和嗜酸性粒细胞/嗜中性粒细胞比率（ENR）较高。结论嗜酸性粒细胞/中性粒细胞计数参数是血液与痰液之间的关系。血液中的嗜酸性粒细胞及其比例（ENR，EMR和ELR）可用于评估COPD恶化中的嗜酸性气道炎症。由于关系薄弱，预测能力差，需要做更多的研究。