BACKGROUND ABO gene polymorphisms have been reported to be associated with the risk of multiple cancers and cardiocerebrovascular diseases. However, the results remained controversial. In this study, we conducted a systematic review and meta-analysis to clarify the association between two SNPs (rs505922 and rs657152) in ABO gene and cancers/cardiocerebrovascular diseases. METHOD All eligible case-control studies come from PubMed, Embase and Web of Science up to Jan. 1, 2019. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the corresponding associations. Sensitivity analysis, publication bias assessment, and heterogeneity test were performed using STATA 12.0. RESULTS A total of nineteen articles involving twenty-two case-control populations were included according to inclusion and exclusion criteria. Twelve populations (20,820 cases and 27,837 controls) were used to evaluate the relationship between rs505922 and overall cancers and nine populations (22,275 cases and 71,549 controls) were included to assess the association between rs505922 and cardiocerebrovascular diseases. The results showed a significant association between the rs505922 polymorphism and cancers (CvsT: OR = 1.13, 95%CI = 1.05-1.22, P = 0.001), and cardiocerebrovascular diseases (OR = 1.36, 95%CI = 1.19-1.57, P < 0.001). Five populations (8660 cases and 10,618 controls) were included to evaluate association between rs657152 and cancers and five populations (8105 cases and 6712 controls) were included to estimate the relationship between rs657152 and cardiocerebrovascular diseases. The result of meta-analysis reveals that rs657152 was significantly associated with cancers (OR = 1.18, 95%CI = 1.13-1.23, P < 0.001) and cardiocerebrovascular diseases (OR = 1.54, 95%CI = 1.24-1.92, P < 0.001). CONCLUSION Our study suggested that ABO polymorphisms might serve as a risk factor of pancreatic cancers and cardiocerebrovascular diseases.

中文翻译：

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ABO基因多态性与胰腺癌/心脑血管疾病的关联：一项荟萃分析。

背景技术据报道，ABO基因多态性与多种癌症和心脑血管疾病的风险有关。但是，结果仍然存在争议。在这项研究中，我们进行了系统的综述和荟萃分析，以阐明ABO基因中的两个SNP（rs505922和rs657152）与癌症/心血管疾病之间的关联。方法截至2019年1月1日，所有符合条件的病例对照研究均来自PubMed，Embase和Web of Science。采用具有95％置信区间（CI）的合并比值比（OR）评估相应的关联性。使用STATA 12.0进行了敏感性分析，发布偏倚评估和异质性测试。结果根据纳入和排除标准，共纳入19篇文章，涉及22个病例对照人群。12个人群（20,820例和27,837例对照）用于评估rs505922与总体癌症之间的关系，包括9个人群（22,275例和71,549例对照）以评估rs505922与心脑血管疾病之间的关联。结果显示rs505922基因多态性与癌症（CvsT：OR = 1.13，95％CI = 1.05-1.22，P = 0.001）和心脑血管疾病（OR = 1.36，95％CI = 1.19-1.57，P < 0.001）。包括5个人群（8660例和10,618个对照）以评估rs657152与癌症之间的关联，并包括5个人群（8105例和6712对照）以评估rs657152与心脑血管疾病之间的关系。荟萃分析的结果显示rs657152与癌症（OR = 1.18，95％CI = 1.13-1.23，P <0.001）和心脑血管疾病（OR = 1.54，95％CI = 1.24-1.92，P <0.001）显着相关）。结论我们的研究提示ABO基因多态性可能是胰腺癌和心脑血管疾病的危险因素。