For metastasis to occur, cancer cells must exocytose proteases, like matrix metalloproteinases (MMPs), that are key in extracellular matrix (ECM) degradation. Growing evidence suggests that cancer cells use distinct spatial and temporal clustering patterns or organizing ‘elements’ that facilitate secretory vesicle fusion and the subsequent exocytosis of proteins that contribute to metastasis.

中文翻译：

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组织“元素”：促进胞吐和促进转移

为了发生转移，癌细胞必须胞吐蛋白酶，例如基质金属蛋白酶（MMP），这是细胞外基质（ECM）降解的关键。越来越多的证据表明，癌细胞利用不同的时空聚集模式或组织“元素”来促进分泌性囊泡融合以及随后引起转移的蛋白质的胞吐作用。