Interstitial lung disease (ILD) is a term used to describe a heterogeneous group of lung disorders with characteristic clinical and imaging features. Patients with ILD are at an increased risk of developing non-small cell lung cancer and are frequently medically comorbid often precluding operative management. In this scenario, radiotherapy (RT) is generally recommended however ILD is known to increase the risk of RT-related toxicity. Recommendations for treatment with appropriately individualized risks and benefits are thus dependent on integration of patient-, ILD-, and cancer-specific factors. We aim to provide an overview of ILD for the thoracic radiation oncologist, an assessment of risk of thoracic RT in ILD patients, and evidence based recommendations for treatment for a variety of clinical scenarios.

中文翻译：

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间质性肺病和胸部放疗入门

间质性肺病 (ILD) 是一个术语，用于描述具有特征性临床和影像学特征的一组异质性肺病。ILD 患者发生非小细胞肺癌的风险增加，并且经常有医学合并症，通常无法进行手术治疗。在这种情况下，通常建议放疗 (RT)，但已知 ILD 会增加放疗相关毒性的风险。因此，具有适当个性化风险和收益的治疗建议取决于患者、ILD 和癌症特定因素的整合。我们旨在为胸部放射肿瘤学家提供 ILD 概述、ILD 患者胸部放疗风险的评估以及针对各种临床情况的循证治疗建议。