Transition‐Metal‐Free Selective C(sp3)−H Thiolation of Arylacetamides with Substituted Benzenethiols, Aryl Sulfenylchlorides and Diaryl Disulfides,Asian Journal of Organic Chemistry

当前位置： X-MOL 学术 › Asian J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Transition‐Metal‐Free Selective C(sp3)−H Thiolation of Arylacetamides with Substituted Benzenethiols, Aryl Sulfenylchlorides and Diaryl Disulfides
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-03-13 , DOI: 10.1002/ajoc.202000083
Changying Liu ₁ , Zheyu Li ₁ , Zhengyun Weng ₁ , Xinyue Fang ₁ , Fei Zhao ₁ , Kehui Tang ₁ , Jianyang Chen ₂ , Wenbo Ma ₁

Affiliation

A synthetic method for the preparation of unsymmetrical 2‐arylthioacetamides though direct C(sp³)−H thiolation of arylacetamides with readily available substituted thiols, sulfenylchlorides and disulfides have been developed. Our strategy features a green reaction medium with ample substrate scope, affording the mono‐thiolated aryl acetic acid derivatives in moderate to good yields in the presence of weak bases without any transition‐metal catalyst.

中文翻译：

芳基乙酰胺与取代的苯硫醇，芳基亚硫酰氯和二芳基二硫化物的无过渡金属选择性C（sp3）-H硫代化

已经开发了一种通过不饱和2-巯基乙酰胺与容易获得的取代硫醇，亚硫酰氯和二硫键直接进行C（sp ³）-H巯基化反应来制备不对称2-芳基硫代乙酰胺的合成方法。我们的策略以绿色反应介质为基础，该介质具有足够的底物范围，在弱碱存在下无需任何过渡金属催化剂的情况下，以中等到良好的产率提供单硫醇化的芳基乙酸衍生物。

更新日期：2020-04-21

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11