Specialized medial prefrontal-amygdala coordination in other-regarding decision preference.,Nature Neuroscience

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Specialized medial prefrontal-amygdala coordination in other-regarding decision preference.
Nature Neuroscience ( IF 21.2 ) Pub Date : 2020-02-24 , DOI: 10.1038/s41593-020-0593-y
Olga Dal Monte _{1,

2} , Cheng C J Chu ₁ , Nicholas A Fagan ₁ , Steve W C Chang _{1,

3,

4}

Affiliation

Social behaviors recruit multiple cognitive operations that require interactions between cortical and subcortical brain regions. Interareal synchrony may facilitate such interactions between cortical and subcortical neural populations. However, it remains unknown how neurons from different nodes in the social brain network interact during social decision-making. Here we investigated oscillatory neuronal interactions between the basolateral amygdala and the rostral anterior cingulate gyrus of the medial prefrontal cortex while monkeys expressed context-dependent positive or negative other-regarding preference (ORP), whereby decisions affected the reward received by another monkey. Synchronization between the two nodes was enhanced for a positive ORP but suppressed for a negative ORP. These interactions occurred in beta and gamma frequency bands depending on the area contributing the spikes, exhibited a specific directionality of information flow associated with a positive ORP and could be used to decode social decisions. These findings suggest that specialized coordination in the medial prefrontal-amygdala network underlies social-decision preferences.

中文翻译：

在其他有关决策偏好方面的专门内侧前额-杏仁核协调。

社会行为招募了需要认知皮质和皮质下大脑区域之间相互作用的多种认知操作。区域间同步可以促进皮质和皮质下神经群体之间的这种相互作用。然而，在社会决策过程中，来自社会大脑网络中不同节点的神经元如何相互作用仍是未知的。在这里，我们研究了内侧前额叶皮层的基底外侧杏仁核和喙状前扣带回之间的振荡神经元相互作用，而猴子则表达了上下文相关的阳性或阴性其他相关偏好（ORP），从而决定了另一只猴子获得的报酬。对于正的ORP，增强了两个节点之间的同步，但对于负的ORP，抑制了同步。这些相互作用发生在beta和gamma频带中，具体取决于造成尖峰的区域，显示出与正ORP相关的信息流的特定方向性，可用于解码社会决策。这些发现表明，内侧前额-杏仁核网络中的专门协调是社会决策偏好的基础。

更新日期：2020-02-24

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